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Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.
- M. Kohno, H. Hasegawa, +4 authors M. Yasukawa
- Medicine, Biology
- Biochemical and biophysical research…
- 1 September 2006
An orphan G-protein-coupled receptor, GPR18, was cloned on the basis of degenerate-oligonucleotide PCR analysis of HUT 102 cells using primers designed from the conservative regions of the human… Expand
Adrenomedullin as a novel antiproliferative factor of vascular smooth muscle cells
Objective The present study was designed to examine whether adrenomedullin affects fetal calf serum (FCS) stimulated proliferation in cultured rat vascular smooth muscle cells (VSMCs). Methods Rat… Expand
Brain natriuretic peptide as a marker for hypertensive left ventricular hypertrophy: changes during 1-year antihypertensive therapy with angiotensin-converting enzyme inhibitor.
PURPOSE Secretion of brain natriuretic peptide (BNP), a cardiac hormone, is accelerated via hypertrophied ventricles in experimental hypertension. The present study examined whether regression of… Expand
Adrenomedullin as a novel antimigration factor of vascular smooth muscle cells.
The present study investigated the effect of adrenomedullin, a novel vasorelaxant peptide, on the migration of cultured rat vascular smooth muscle cells (SMCs) by using the Boyden-chamber method.… Expand
Brain natriuretic peptide as a cardiac hormone in essential hypertension.
PURPOSE A natriuretic peptide, brain natriuretic peptide (BNP), has been isolated from porcine hearts. We performed this study to determine if BNP is secreted from the heart and to identify changes,… Expand
Antagonist of monocyte chemoattractant protein 1 ameliorates the initiation and progression of lupus nephritis and renal vasculitis in MRL/lpr mice.
OBJECTIVE To examine whether chemokine antagonists inhibit the initiation and progression of lupus nephritis in MRL/lpr mice. METHODS NH(2)-terminal-truncated monocyte chemoattractant protein 1… Expand
CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase
- M. Kohno, H. Hasegawa, M. Miyake, T. Yamamoto, S. Fujita
- Biology, Medicine
- International journal of cancer
- 20 January 2002
We have examined the role of the protein CD151 in cell motility, invasion and metastasis of cancer cells by using CD151‐overexpressing cells prepared by transfection of CD151 cDNA into three cancer… Expand
Urocortin expression in synovium of patients with rheumatoid arthritis and osteoarthritis: relation to inflammatory activity.
- M. Kohno, Y. Kawahito, +9 authors H. Sano
- The Journal of clinical endocrinology and…
- 1 September 2001
Peripherally produced CRH acts as a local auto/paracrine proinflammatory agent. Urocortin is a new member of the CRH family that acts through the family of CRH receptors. In this study, we… Expand
Plasma adrenomedullin concentrations in essential hypertension.
We designed the present study to assess any changes in plasma concentrations of the novel vasorelaxant peptide adrenomedullin in patients with essential hypertension. Plasma adrenomedullin… Expand
Hypertension associated with endothelin-secreting malignant hemangioendothelioma.
Endothelin-1, a potent vasoconstrictor peptide that has recently been isolated from the supernatant of cultured porcine aortic endothelial cells (1), is involved in some vascular disorders (2). Mal...