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Genetic rearrangements in the pathogenicity locus of Clostridium difficile strain 8864 – implications for transcription, expression and enzymatic activity of toxins A and B
Abstract The pathogenicity locus (PaLoc) of Clostridium difficile isolate 8864 was investigated to locate genetic rearrangements that would explain the exceptional pathogenicity of this particularExpand
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Targeted metabolomics for biomarker discovery.
Metabolomics is a truly interdisciplinary field of science, which combines analytical chemistry, platform technology, mass spectrometry, and NMR spectroscopy with sophisticated data analysis. Expand
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Targeted Metabolomics for Biomarker Discovery
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Bacteria on smartphone touchscreens in a German university setting and evaluation of two popular cleaning methods using commercially available cleaning products
Smartphone touchscreens are known as pathogen carriers in clinical environments. However, despite a rapidly growing number of smartphone users worldwide, little is known about bacterial contaminationExpand
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“Targeted Metabolomics” in der Biomarkerforschung
Der Begriff “Metabolomics” bezeichnet ein wissenschaftliches Betatigungsfeld, das im ureigenen Sinn interdisziplinar ist und in dem analytische Chemie, Plattformtechnologie, Massenspektrometrie undExpand
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Development and validation of predictive molecular signatures.
  • M. Kohl
  • Computer Science, Medicine
  • Current molecular medicine
  • 28 February 2010
We describe the necessary development and validation steps including recent results of the MAQC project (MAQC-II) and emphasise on potential pitfalls. Expand
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Imaging of superficially growing tumors by delayed observation of laser-induced fluorescence
Images of superficially growing tumors marked with prophyrin-based photosensitizers (Photofrin II, P4P-mD) were recorded in vivo by delayed observation of fluorescence following pulsed laserExpand
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distrMod | an S4-class based package for statistical models
The S4 concept ([1]) is a strong tool for writing unied algorithms. As an example for this in R ([3]), we present a new package distrMod for a conceptual implementation of statistical models based onExpand
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