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[Development of new in vitro chemosensitivity test using collagen gel droplet embedded culture and its clinical usefulness].
- H. Kobayashi, K. Tanisaka, +7 authors M. Yamada
- Gan to kagaku ryoho. Cancer & chemotherapy
- 1 November 1995
We developed a new in vitro assay for chemosensitivity test using collagen gel droplet embedded culture and image analysis. In this in vitro assay, we successfully minimized the cancer cell number… Expand
Telopeptide‐depleted bovine skin collagen as a carrier for bone morphogenetic protein
- K. Takaoka, M. Koezuka, H. Nakahara
- Journal of orthopaedic research : official…
- 1 November 1991
The telopeptide of type I collagen is thought to be responsible for causing immunogenic response when introduced into xenogenic hosts. To eliminate this problem, solubilized bovine skin collagen was… Expand
Periosteal bone formation elicited by partially purified bone morphogenetic protein.
- H. Nakahara, K. Takaoka, M. Koezuka, K. Sugamoto, T. Tsuda, K. Ono
- Clinical orthopaedics and related research
- 1 February 1989
A small amount of partially purified, water-soluble murine osteosarcoma-derived bone morphogenetic protein (BMP) was implanted into the dorsal muscles of mice in combination with calf skin gelatin or… Expand
Drug sensitivity test for primary culture of human cancer-cells using collagen gel embedded culture and image-analysis.
- M. Koezuka, N. Kondo, +5 authors H. Asano
- Biology, Medicine
- International journal of oncology
- 1 June 1993
A new drug sensitivity assay method using the collagen gel embedded culture and image analysis was developed. Human cancer cells cultured in collagen gels showed extremely high cloning efficiency and… Expand
In vitro-in vivo correlation in anticancer drug sensitivity test using AUC-based concentrations and collagen gel droplet-embedded culture.
To improve the ability of an in vitro drug sensitivity test to predict in vivo effects, we applied a drug concentration that was pharmacokinetically equivalent to plasma levels and collagen gel… Expand
Morphogenesis of human tumor cells cultured in collagen gel and drug sensitivity for the cultured cells
Productivity of thyroglobulin and thyroid hormone on human thyroid cell in collagen gel culture.
Thyroid cells obtained from 21 normal human thyroid tissue samples and 17 tissue samples from diseased thyroid, including one of Graves disease, 4 with follicular adenoma, 11 with papillary… Expand
[Morphological study of human thyroid papillary carcinoma cells in collagen gel culture].
Human thyroid papillary carcinoma cells (surgical materials) were cultured in a monolayer or a collagen gel system. In the monolayer culture, degeneration and necrosis of cancer cells were observed… Expand
Morphological and functional differentiation of human thyroid cells in collagen gel culture.
- T. Kusunoki, S. Nishida, M. Koezuka, K. Murata, T. Tomura
- Medicine, Biology
- Auris, nasus, larynx
- 1 November 2001
OBJECTIVE Cultured human thyroid cells in collagen gel culture were examined on cell morphology and the production of thyroglobulin (Tg), triiodothyronine (T3) and thyroxine (T4) which are components… Expand
[Chemotherapy for metastatic brain tumors with CDDP and other agents: correlation between chemotherapeutic effects and the results of in vitro chemosensitivity tests using collagen gel-embedded…
- H. Nakagawa, H. Kobayashi, +6 authors K. Tsuruzono
- No shinkei geka. Neurological surgery
- 1 June 1994
Chemotherapy with CDDP and/or other agents was performed in 15 patients after removal of metastatic brain tumors. A chemosensitivity test using a system of collagen gel-embedded culture and… Expand