• Publications
  • Influence
Increased expression of connexins 26 and 43 in lymph node metastases of breast cancer
Background: Gap junctions are intercellular channels composed of connexins, which mediate the direct passage of small molecules between neighbouring cells. They are involved in regulation of cellExpand
  • 130
  • 10
Increased Expression of Leptin and the Leptin Receptor as a Marker of Breast Cancer Progression: Possible Role of Obesity-Related Stimuli
Purpose: Recent in vitro studies suggested that the autocrine leptin loop might contribute to breast cancer development by enhancing cell growth and survival. To evaluate whether the leptin systemExpand
  • 297
  • 9
  • PDF
Proteolytic-antiproteolytic balance and its regulation in carcinogenesis.
Cancer development is essentially a tissue remodeling process in which normal tissue is substituted with cancer tissue. A crucial role in this process is attributed to proteolytic degradation of theExpand
  • 159
  • 9
Lipid peroxidation and antioxidant status in colorectal cancer.
AIM Reactive oxygen species (ROS) can induce carcinogenesis via DNA injury. Both enzymatic and non-enzymatic parameters participate in cell protection against harmful influence of oxidative stress.Expand
  • 201
  • 4
Overexpression of the obesity hormone leptin in human colorectal cancer
Background: Leptin is an adipocyte-derived neurohormone, high levels of which are found in obese individuals. Leptin controls energy expenditure, acting in the brain, and regulates differentExpand
  • 98
  • 4
Connexins 26 and 43 correlate with Bak, but not with Bcl-2 protein in breast cancer.
Apoptosis is a process associated with development and progression of breast cancer. The association between connexins and programmed cell death has only been demonstrated in a few studies. The aimExpand
  • 45
  • 4
Expression of Leptin, Leptin Receptor, and Hypoxia‐Inducible Factor 1α in Human Endometrial Cancer
Abstract:  Recent studies suggested that Ob (Ob) and its receptor (ObR) could be involved in the pathogenesis of various human malignancies, among others in endometrial cancer. Moreover, hypoxia,Expand
  • 80
  • 3
Expression of connexins 26, 32 and 43 in the human colon--an immunohistochemical study.
Gap junctional intercellular communication (GJIC) is a mechanism for direct cell-to-cell signalling and is mediated by gap junctions (GJs), which consist of proteins called connexins (Cxs). GJICExpand
  • 30
  • 3
  • PDF
Expression of insulin receptor substrate 1 in primary breast cancer and lymph node metastases
Background: Insulin receptor substrate 1 (IRS-1) transmits signals from the insulin-like growth factor I receptor (IGF-IR) and insulin receptor (IR) and has been associated with the pathogenesis ofExpand
  • 55
  • 3
Stimulatory effect of cisplatin on production of lipid peroxidation in renal tissues.
Cisplatin (cis-diamminedichloroplatinum II), an anticancer chemotherapeutic agent with the dose-limiting side effect of nephrotoxicity, caused a statistically significant increase in lipidExpand
  • 101
  • 2