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Protein phosphatase 1 is a molecular constraint on learning and memory
TLDR
It is shown that protein phosphatase 1 (PP1) determines the efficacy of learning and memory by limiting acquisition and favouring memory decline, and inhibition of PP1 prolongs memory when induced after learning, suggesting that PP1 also promotes forgetting. Expand
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis
TLDR
The data presented here characterize a molecular pathway from Wnt signaling to a transcriptional target leading to granule cell differentiation within the adult brain and identify a stage-specific function for Prox1 in the process of adult neurogenesis. Expand
Gene Expression Profiling of Neural Stem Cells and Their Neuronal Progeny Reveals IGF2 as a Regulator of Adult Hippocampal Neurogenesis
TLDR
It is shown that IGF2 selectively controls proliferation of DG NSCs in vitro and in vivo through AKT-dependent signaling and is identified as a novel regulator of adult neurogenesis. Expand
Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis
TLDR
It is shown that fatty acid synthase (Fasn), the key enzyme of de novo lipogenesis, is highly active in adult NSPC and that conditional deletion of Fasn in mouse NSPCs impairs adult neurogenesis. Expand
Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice.
TLDR
An early role of intracellular Abeta in the pathophysiological cascade leading to beta-amyloid formation and functional impairment in Alzheimer's disease is supported. Expand
Intracellular Aβ and cognitive deficits precede β-amyloid deposition in transgenic arcAβ mice
TLDR
The co-incidence of intrACEllular A deposits with behavioral deficits support an early role of intracellular A in the pathophysiological cascade leading to -amyloid formation and functional impairment. Expand
Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology.
TLDR
It is reported that the 'Readthrough' A ChE-R splice variant, which differs from AChE-S in its 26 C-terminal residues, inversely exerts neuroprotective effects from amyloid beta (Abeta) induced toxicity, revealing a previously unforeseen linkage between cholinergic andAmyloidogenic events. Expand
Dendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease
TLDR
This review will describe recent findings and discoveries on the loss or alteration of dendritic spines induced by the amyloid β (Aβ) peptide in the context of AD. Expand
A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity
TLDR
It is shown that the rate of fatty acid oxidation (FAO) regulates the activity of NSPCs, and an instructive role for fatty acid metabolism in regulating NSPC activity is suggested. Expand
The role of fatty acid β-oxidation in lymphangiogenesis
TLDR
In transgenic mouse models, LEC-specific loss of CPT1A, a rate-controlling enzyme in fatty acid β-oxidation, impairs lymphatic development and replenishing acetyl coenzyme A by supplementing acetate rescues this process in vivo. Expand
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