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Mutation rate in human microsatellites: influence of the structure and length of the tandem repeat.
- B. Brinkmann, M. Klintschar, F. Neuhuber, J. Hühne, B. Rolf
- BiologyAmerican journal of human genetics
- 1 June 1998
The data demonstrate that mutation rates of different loci can differ by several orders of magnitude and that different alleles at one locus exhibit different mutation rates.
Evidence of fetal microchimerism in Hashimoto's thyroiditis.
- M. Klintschar, P. Schwaiger, S. Mannweiler, S. Regauer, M. Kleiber
- Biology, MedicineThe Journal of clinical endocrinology and…
- 1 June 2001
The results show that microchimerism is significantly more common in Hashimoto patients than in patients suffering from nodular goiter, and suggest that micro chimerism might play a role in the development of Hashimoto's disease, although this cannot completely eliminate the hypothesis that microChimerist is just an "innocent bystander" in a process triggered by other mechanisms.
Induction of cardiac FGF23/FGFR4 expression is associated with left ventricular hypertrophy in patients with chronic kidney disease.
- M. Leifheit-Nestler, R. große Siemer, D. Haffner
- Medicine, BiologyNephrology, dialysis, transplantation : official…
- 1 July 2016
A strong association between LVH and enhanced expression levels of FGF23, FGFR4 and calcineurin, activation of NFAT and reduced levels of soluble Klotho in the myocardium of patients with CKD is indicated.
Massive injury to the heart after attempted active compression-decompression cardiopulmonary resuscitation
The autopsy revealed that death was due to myocardial infarction complicated by rupture of the infarcted area and pericardial tamponade was diagnosed, adding to the suspicion of an increased risk of cardiac injuries when using an ACD device for cardiac massage.
Polymerase slippage in relation to the uniformity of tetrameric repeat stretches.
A functional polymorphism in the tyrosine hydroxylase gene indicates a role of noradrenalinergic signaling in sudden infant death syndrome.
Y-Chromosome Analysis in Egypt Suggests a Genetic Regional Continuity in Northeastern Africa
The Y-chromosome gene pool in the modern Egyptian population reflects a mixture of European, Middle Eastern, and African characteristics, highlighting the importance of ancient and recent migration waves, followed by gene flow, in the region.
Fibroblast growth factor 23 is induced by an activated renin–angiotensin–aldosterone system in cardiac myocytes and promotes the pro-fibrotic crosstalk between cardiac myocytes and fibroblasts
- M. Leifheit-Nestler, Felix Kirchhoff, D. Haffner
- Biology, MedicineNephrology, dialysis, transplantation : official…
- 1 October 2018
The data demonstrate that activated RAAS induces FGF23 expression in cardiac myocytes and thereby stimulates a pro-fibrotic crosstalk between cardiac myocyte and fibroblasts, which may contribute to myocardial fibrosis in CKD.
Fetal microchimerism in Hashimoto's thyroiditis: a quantitative approach.
- M. Klintschar, U. Immel, C. Hoang‐Vu
- Medicine, BiologyEuropean journal of endocrinology
- 1 February 2006
It is concluded that the tested blood group systems have no effect on fetal MCH, and mothers both with and without MCH showed the same rate of mother/child incompatibilities for the ABO and rhesus systems.
Evaluation of an alkaline lysis method for the extraction of DNA from whole blood and forensic stains for STR analysis.
A modified alkaline lysis protocol for extracting DNA from forensically relevant specimens is evaluated and compared with the chelex 100 method and proved to yield DNA suitable for typing longer STRs by using dye-labeled primers and capillary electrophoresis.