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Genetic association of apolipoprotein E with age-related macular degeneration.
- C. Klaver, M. Kliffen, +5 authors P. T. D. de Jong
- Biology, Medicine
- American journal of human genetics
- 1 July 1998
Age-related macular degeneration (AMD) is the most common geriatric eye disorder leading to blindness and is characterized by degeneration of the neuroepithelium in the macular area of the eye.… Expand
Increased expression of angiogenic growth factors in age-related maculopathy
- M. Kliffen, H. S. Sharma, C. Mooy, S. Kerkvliet, P. T. D. de Jong
- The British journal of ophthalmology
- 1 February 1997
AIMS/BACKGROUND The late stages of age-related maculopathy (ARM), especially neovascular macular degeneration (ARMD), can severely affect central vision and are the main cause of blindness in the… Expand
Clinical relevance of melanoma micrometastases (<0.1 mm) in sentinel nodes: are these nodes to be considered negative?
- A. V. van Akkooi, J. D. de Wilt, +4 authors M. Kliffen
- Annals of oncology : official journal of the…
- 1 October 2006
As only about 20% of sentinel node (SN) positive melanoma patients have additional non-SN lymph node involvement in the Completion Lymph Node Dissection (CLND) specimen, we tried to identify a SN… Expand
Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience.
Diagnostic value of OCT3/4 for pre‐invasive and invasive testicular germ cell tumours
Human testicular germ cell tumours of adolescents and adults (TGCTs), the seminomatous and non‐seminomatous germ cell tumours, show morphological and biological similarities to normal embryonic… Expand
Morphologic changes in age‐related maculopathy
- M. Kliffen, T. L. van der Schaft, C. Mooy, P. T. D. de Jong
- Microscopy research and technique
- 15 January 1997
Age‐related maculopathy (ARM) is a degenerative disorder of the central part of the retina with a rising prevalence in patients 50 years of age and older, and comprises different histopathological… Expand
Soft tissue sarcomas at a glance: clinical, histological, and MR imaging features of malignant extremity soft tissue tumors
Soft tissue sarcomas comprise approximately 1% of malignant tumors. There are more than 50 subtypes, but pleomorphic sarcoma, liposarcoma, leiomyosarcoma, synovial sarcoma, and malignant peripheral… Expand
Neoadjuvant chemoradiotherapy plus surgery versus active surveillance for oesophageal cancer: a stepped-wedge cluster randomised trial
BackgroundNeoadjuvant chemoradiotherapy (nCRT) plus surgery is a standard treatment for locally advanced oesophageal cancer. With this treatment, 29% of patients have a pathologically complete… Expand
Decreased coronary flow reserve in hypertrophic cardiomyopathy is related to remodeling of the coronary microcirculation.
BACKGROUND Ischemia occurs frequently in hypertrophic cardiomyopathy (HCM) without evidence of epicardial stenosis. This study evaluates the hypothesis that the occurrence of ischemia in HCM is… Expand
High positive sentinel node identification rate by EORTC melanoma group protocol. Prognostic indicators of metastatic patterns after sentinel node biopsy in melanoma.
- A. V. van Akkooi, J. D. de Wilt, +4 authors A. Eggermont
- European journal of cancer
- 1 February 2006
Methods to work-up sentinel nodes (SN) vary considerably between institutes. This single institution study evaluated the positive SN-identification rate of the EORTC Melanoma Group (MG) protocol and… Expand