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Visualization of the Calcitonin Receptor-like Receptor and Its Receptor Activity-modifying Proteins during Internalization and Recycling*
The CRLR is endocytosed together with RAMPs via clathrin-coated vesicles, and both the internalized molecules are targeted to the degradative pathway. Expand
Molecular Cloning of a Novel Human CC Chemokine (Eotaxin-3) That Is a Functional Ligand of CC Chemokine Receptor 3*
Previously, we mapped the novel CC chemokine myeloid progenitor inhibitory factor 2 (MPIF-2)/eotaxin-2 to chromosome 7q11.23 (Nomiyama, H., Osborne, L. R., Imai, T., Kusuda, J., Miura, R., Tsui,Expand
Identification of a mouse eosinophil receptor for the CC chemokine eotaxin.
  • J. Gao, A. Sen, +4 authors A. Luster
  • Chemistry, Medicine
  • Biochemical and biophysical research…
  • 25 June 1996
RNA for the receptor was abundant in primary eosinophils, but at low levels in neutrophils and macrophages, which makes this receptor the best known candidate to mediate mouse eOSinophil responses to eotaxin. Expand
Chemokines induce eosinophil degranulation through CCR-3.
It is suggested that chemokine-induced eosinophil degranulation, a major effector of eos inophil functions, is mediated through only CCR3, although some non-CCR3 ligands induce calcium influx in eOSinophils. Expand
Contrasting effect of alpha/beta- and gamma-interferons on expression of macrophage Ia antigens
Results indicate that IFN-alpha and -beta, which can be produced in the course of self-defense responses and during ontogeny, may contribute to the down-regulation of macrophage Ia expression. Expand
Down-regulation of macrophage Ia mRNA expression by interferon (IFN)-α and IFN-β mediated by de novo synthesized protein☆
Results indicate that the augmentation of induction and/or accumulation of MHC mRNA by IFNs is not dependent on the de novo synthesis of protein, but the down-regulation of class II mRNA level by IFN-β is mediated by some newly synthesized protein(s). Expand
Effect of Recombinant Human Interferon-αA/D on in Vivo Murine Tumor Cell Growth
Results of in vitro experiments indicate that Mo are very probably activated by the synergism of A/D-IFN and Mo-activating factor(s) produced by lymphoid cells in tumor-bearing mice. Expand
Neuraminidase-treated macrophages stimulate allogenic CD8+ T cells in the presence of exogenous interleukin 2
The data suggest that most macrophages and small B cells lack three important functions of dendritic cells: a T cell-binding function that can be remedied by neuraminidase treatment, an T cell growth factor-inducing function that could be bypassed with exogenous IL-2, and anIL-2 responsiveness function that is required by CD4+ lymphocytes. Expand
The effects of eotaxin on the surface adhesion molecules of endothelial cells and on eosinophil adhesion to microvascular endothelial cells.
It is suggested that eotaxin regulates eosinophil accumulation to the nasal mucosa through its effect on the adhesion molecules on microvascular endothelial cells. Expand
Development of a sensitive enzyme-linked immunosorbent assay for eotaxin and measurement of its levels in human blood.
The new ELISA method developed is an accurate and useful method for quantifying human eotaxin in blood and demonstrates that the process of preparing blood samples affects the measurement of the eOTaxin levels. Expand