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Molecular genetic identification of a candidate receptor gene for sweet taste.
A cDNA clone encoding a novel member of the putative taste receptor T1R family, designated T1R3, was isolated from circumvallate papillae of the mouse tongue using degenerate primers. ReverseExpand
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Phosphorylation at Serine 10, a Major Phosphorylation Site of p27 Kip1 , Increases Its Protein Stability*
The association of the p27 Kip1 protein with cyclin and cyclin-dependent kinase complexes inhibits their kinase activities and contributes to the control of cell proliferation. The p27 Kip1 proteinExpand
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Characterization of a Novel Mammalian SUMO-1/Smt3-specific Isopeptidase, a Homologue of Rat Axam, Which Is an Axin-binding Protein Promoting β-Catenin Degradation*
A novel SUMO-1/Smt3-specific isopeptidase, SMT3IP2/Axam2 (Smt3-specific isopeptidase 2), was cloned and characterized. The catalytic domains in the carboxyl-terminal region were very much similar toExpand
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A Sveinsson's chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ.
  • M. Kitagawa
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 5 October 2007
Sveinsson's chorioretinal atrophy (SCRA) is an autosomal dominant eye disease characterized by bilateral chorioretinal degeneration. A missense mutation in the gene encoding the transcription factorExpand
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Inhibition of Mcm4,6,7 Helicase Activity by Phosphorylation with Cyclin A/Cdk2*
A strong body of evidence indicates that cyclin-dependent protein kinases are required not only for the initiation of DNA replication but also for preventing over-replication in eukaryotic cells. McmExpand
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Microarray analysis of the genes induced by tetracycline-regulated expression of NDRF/NeuroD2 in P19 cells.
NeuroD-related factor (NDRF)/NeuroD2 is a basic helix-loop-helix (bHLH) protein that plays important roles in neuronal development. To elucidate the NDRF transcription network, we used mouse cDNAExpand
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A Protein Kinase, PKN, Accumulates in Alzheimer Neurofibrillary Tangles and Associated Endoplasmic Reticulum-Derived Vesicles and Phosphorylates Tau Protein
A possible role for a protein kinase, PKN, a fatty acid-activated serine/threonine kinase with a catalytic domain homologous to the protein kinase C family and a direct target for Rho, wasExpand
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Alternative splicing variants of the human DBL (MCF-2) proto-oncogene.
The DBL (MCF-2) proto-oncogene is a prototype guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. In this communication we describe the isolation of three novelExpand
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Phf14, a Novel Regulator of Mesenchyme Growth via Platelet-derived Growth Factor (PDGF) Receptor-α*
Background: Phf14 is identified as a novel gene that regulates proliferation of mesenchymal cells. Results: Phf14-null mice show interstitial pulmonary hyperplasia and mesenchymal fibroblasts exhibitExpand
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Nucleotide Sequence of the Arginine Deiminase Gene of Mycoplasma hominis
The arginine deiminase gene of Mycoplasma hominis was amplified by the polymerase chain reaction, and its entire nucleotide sequence was determined. This gene consists of 1227 base pairs encoding 409Expand
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