• Publications
  • Influence
Preferential radiosensitization in p53-mutated human tumour cell lines by pentoxifylline-mediated disruption of the G2/M checkpoint control
TLDR
Since PTX was less effective in cells expressing intact p53, the application of PTX suggests a promising strategy of pharmacological disruption of the G2/M checkpoint control by which preferentially radiation-resistant tumours with defective p53 function might be rendered more sensitive to ionizing radiation. Expand
Synthetic macromolecular drug carriers: biodistribution of poly[(N-2-hydroxypropyl)methacrylamide] copolymers and their accumulation in solid rat tumors.
TLDR
The results demonstrate the influence of the molecular weight of the synthetic polymer pHPMA on plasma circulation time, excretion and organ clearance, and are of fundamental interest for ongoing studies on the pharmacokinetics of synthetic polymers. Expand
Increased MIBG uptake after transfer of the human norepinephrine transporter gene in rat hepatoma.
TLDR
Transduction of the hNET gene enables Morris hepatoma cells to accumulate norepinephrine and MIBG, however, the retention of M IBG is brief; therefore, the absorbed dose of radiation in vivo is not expected to be therapeutically effective. Expand
Allosteric MEK1/2 inhibitor refametinib (BAY 86-9766) in combination with sorafenib exhibits antitumor activity in preclinical murine and rat models of hepatocellular carcinoma.
TLDR
Bay 86-9766 shows potent single-agent antitumor activity and acts synergistically in combination with sorafenib in preclinical HCC models and these results support the ongoing clinical development of BAY 86- 9766 and sorafinib in advanced HCC. Expand
Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers.
TLDR
Tumor-to-organ ratios were comparable to unmodified control for the majority of chemically modifiedCopolymers, indicating that functionalization does not necessarily affect the tumor targeting ability of the copolymers and suggesting that HPMA copolymer-based drug delivery systems may prove to be attractive tools for more effectively treating various forms of advanced solid malignancy. Expand
Enhanced iodide transport after transfer of the human sodium iodide symporter gene is associated with lack of retention and low absorbed dose
TLDR
Although transduction of the hNIS gene induces iodide transport in rat prostate adenocarcinoma a rapid efflux occurs, which leads to a low absorbed dose in genetically modified tumors, which needs to be defined leading to iodide trapping. Expand
Antitumor effects of regorafenib and sorafenib in preclinical models of hepatocellular carcinoma
TLDR
Overall, both regorafenib and sorafenIB were effective in mouse models of HCC, although several cases showed better regorAFenib activity which may explain the observed efficacy of regoracenib in sorafinib-refractory patients. Expand
SC68896, a Novel Small Molecule Proteasome Inhibitor, Exerts Antiglioma Activity In vitro and In vivo
TLDR
SC68896 is the first proteasome inhibitor that exerts antiglioma activity in vivo and may represent a novel prototype agent for the treatment of malignant gliomas and warrants clinical evaluation. Expand
Detection and cellular localisation of the synthetic soluble macromolecular drug carrier pHPMA
TLDR
How biotin as a label influences the biodistribution of poly(HPMA) was assessed by scintigraphy, autoradiography and histology comparing homopolymer poly( HPMA) with biotin-pHPMA, and the organ distribution patterns of the two polymers correlated well. Expand
Abstract 4262: Regorafenib (BAY 73-4506): A broad spectrum tumor deactivator with high combinability potential and antimetastasis activity
TLDR
In preclinical models regorafenib has shown a high potential as a combination partner with other therapeutic agents such as irinotecan, which may make it suitable as a future backbone for treatment of multiple cancer types. Expand
...
1
2
...