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Neural crest cells contribute to normal aorticopulmonary septation.
By analyzing the hearts of quail-chick chimeras, it was found that neural crest cells at the level of occipital somites 1 to 3 migrate to the region of the aorticopulmonary septum, resulting in common arterial outflow channels or transposition of the great vessels.
Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND
- D. Srivastava, T. Thomas, Q. Lin, M. Kirby, Doris Brown, E. Olson
- Biology, MedicineNature Genetics
- 1 June 1997
The description of the cardiac phenotype of dHAND mutant embryos is the first demonstration of a single gene controlling the formation of the mesodermally derived right ventricle and the neural crest-derived aortic arches and reveals a novel cardiogenic subprogramme for right ventricular development.
Conotruncal myocardium arises from a secondary heart field.
The addition of a secondary myocardium to the primary heart tube provides a new framework for understanding several null mutations in mice that cause defective heart development.
The role of secondary heart field in cardiac development.
Cardiac neural crest cells provide new insight into septation of the cardiac outflow tract: aortic sac to ventricular septal closure.
- K. Waldo, S. Miyagawa‐Tomita, D. Kumiski, M. Kirby
- Biology, MedicineDevelopmental biology
- 15 April 1998
The present study describes the movement of cardiac neural crest cells from the caudal pharyngeal arches into the outflow tract and base of the heart during the period of outflow septation and finds that not all of the condensed mesenchyme in the out flow tract during septations was derived from neural crest.
Model systems for the study of heart development and disease. Cardiac neural crest and conotruncal malformations.
Ablation of the secondary heart field leads to tetralogy of Fallot and pulmonary atresia.
Neural crest and cardiovascular patterning.
It is believed that the neural crest–ablation phenotype provides a prototype for comparison with newer models of Neural crest–related cardiovascular dysmorphogenesis and that changes in myocardial functional development provide a means of understanding the early mortality associated with neural crest-type cardiac dys morphogenesis.
Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart.
Myocardial lineage development.
Much of what is known about specification and maturation of myocardial lineages from studies in several different vertebrate model systems is summarized and compared.