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Anti-inflammatory effect of neolignans newly isolated from the crude drug "Shin-i" (flos Magnoliae).
TLDR
The anti-inflammatory effects of the major components of the dried flower buds of MAGNOLIA SALICIFOLIA were determined using the pouch granuloma method in mice as the neolignans selectively inhibited the granulomas tissue formation but did not affect the exudation of pouch fluid. Expand
[Hypoglycemic activity and mechanisms of extracts from mulberry leaves (folium mori) and cortex mori radicis in streptozotocin-induced diabetic mice].
TLDR
The increase in glucose uptake was a mechanism of hypoglycemic actions by W and A2 of Folium Mori. Expand
Immunohistochemical localization of neuronal nicotinic receptor subtypes at the pre- and postjunctional sites in mouse diaphragm muscle
TLDR
Results provide evidence that the subtypes of postsynaptic nAChR, recognized by the anti-beta 2 and/or anti-alpha 8 mAbs, and the presynaptic n aChR recognize by theAnti-alpha 3 mAb, are present at the neuromuscular junction, in addition to the classical muscle nA ChR. Expand
Enhancement by calcitonin gene‐related peptide of non‐contractile Ca2+‐induced nicotinic receptor desensitization at the mouse neuromuscular junction
TLDR
The findings suggest that the CGRP mobilizes non‐contractile Ca2+ through activation of protein kinase‐A, which in turn may activate protein kinases‐C, then enhance the desensitization of postsynaptic nicotinic AChRs at the neuromuscular junction. Expand
Pharmacological evidence for an interaction between constituents (blend effect) of the Japanese‐Sino medicine “Keishi‐ka‐zyutubu‐tō” in neuromuscular blockade in diabetic mice
TLDR
The results indicated that the preferentially more potent neuromuscular blocking effects of Keishi‐ka‐zyutubu‐tō in diabetic muscles were mainly attributable to β‐eudesmol, a major component of Atractylodes lancea. Expand
Inhibitory effects of anti-rheumatic drugs containing magnosalin, a compound from 'Shin-i' (Flos magnoliae), on the proliferation of synovial cells in rheumatoid arthritis models.
TLDR
Evidence is offered that magnosalin suppresses the proliferation of synovial cells in RA models by inhibiting IL-1alpha-stimulated action. Expand
Inhibitory effects on angiogenesis and pouch fluid exudation by aconite alkaloids in adjuvant‐induced inflammation of the mouse
TLDR
The antiinflammatory effect of a water extract of aconite root and its constituent alkaloids on adjuvant‐induced air pouch granuloma in the mouse was investigated and aconite extracts were equipotentto, hydrocortisone and indomethacin against angiogenesis in chronic inflammation. Expand
Inhibition of compound 48/80-mediated histamine release from isolated rat mast cells by oosponol-related compounds (4-acyl-isocoumarins).
TLDR
The mode of inhibitory action of KIT-302, 4-(4'-carboxy-benzoyl)-isocoumarin, was non-competitive antagonism to compound 48/80 on the mast cells, which was more effective than the simultaneous administration. Expand
Micturition activity of pollen extract: contractile effects on bladder and inhibitory effects on urethral smooth muscle of mouse and pig.
TLDR
The results indicate that by pollen extracts (mainly corn pollen extracts) the urine discharge may be caused by the contractile effect on the bladder, and its inhibitory or relaxingEffect on the urethra. Expand
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