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A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences
  • M. Kimura
  • Biology
    Journal of Molecular Evolution
  • 1 December 1980
TLDR
Some examples were worked out using reported globin sequences to show that synonymous substitutions occur at much higher rates than amino acid-altering substitutions in evolution.
An introduction to population genetics theory
An introduction to population genetics theory , An introduction to population genetics theory , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Estimation of evolutionary distances between homologous nucleotide sequences.
  • M. Kimura
  • Biology
    Proceedings of the National Academy of Sciences…
  • 1981
TLDR
It is pointed out that the rates of synonymous base substitutions not only are very high but also are roughly equal to each other between genes even when amino acid-altering substitution rates are quite different and that this is consistent with the neutral mutation-random drift hypothesis of molecular evolution.
Evolutionary Rate at the Molecular Level
Calculating the rate of evolution in terms of nucleotide substitutions seems to give a value so high that many of the mutations involved must be neutral ones.
A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population*.
TLDR
A new model of mutational production of alleles was proposed and it was shown that for this model the ‘effective’ number of selectively neutral alleles maintained in a population of the effective size N e under mutation rate υ per generation is given by When 4 N e υ is small, this differs little from the conventional formula by Kimura & Crow.
Some Problems of Stochastic Processes in Genetics
TLDR
In the present paper, the following five topics have been selected for mathematical discussion and new results are presented: random assortment of subunits of a gene, process of natural selection in a finite population, chance of fixation of mutant genes, population structure and evolution.
Evolution in Sexual and Asexual Populations
TLDR
The evolution of diploidy from haploidy confers an immediate reduction in the mutation load by concealment of deleterious recessives, but this advantage is lost once a new equilibrium is reached and the development of diPloidy may be because of an immediate advantage rather than because of any permanent benefit.
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