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Purification, characterization and inhibition of dihydropyrimidinase from rat liver.
Dihydropyrimidinase (DHPase) was purified 564-fold over the initial rat liver extract, using heat, ammonium sulfate fractionation, DEAE-Sepharose CL-6B, carboxymethyl-Sepharose CL-6B, hydroxyapatiteExpand
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Purification, characterization and inhibition of D-3-aminoisobutyrate aminotransferase from the rat liver.
D-3-Aminoisobutyrate-pyruvate aminotransferase was purified 2000-fold from rat liver extract using heat treatment, ammonium sulfate fractionation, carboxylmethyl-Sepharose CL-6B, DEAE-SepharoseExpand
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Submitochondrial localization of rat liver beta-alanine-oxoglutarate aminotransferase.
beta-Alanine-oxoglutarate aminotransferase from rat liver was mainly distributed in the mitochondrial fraction, while beta-ureidopropionase, the last one of uracil-metabolizing enzymes toExpand
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Effect of vitamin B2 deficiency on rat liver dihydropyrimidine dehydrogenase activity.
Effect of vitamin B2 deficiency on rat liver dihydropyrimidine dehydrogenase was investigated. It was found that the purified enzyme contains 2 mol flavin per molecule, which consists of equalExpand
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Effect of pyridoxine deficiency and prednisolone on beta-alanine-oxoglutarate aminotransferase and D-3-aminoisobutyrate aminotransferase in rat liver and kidney.
beta-Alanine-oxoglutarate aminotransferase (beta-Ala-TI) was found to be distributed mainly in liver, brain, kidney, and testis (decreasing order of enzyme activity in the rat). D-3-AminoisobutyrateExpand
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Identity of D-3-aminoisobutyrate-pyruvate aminotransferase with alanine-glyoxylate aminotransferase 2.
D-3-Aminoisobutyrate-pyruvate aminotransferase (EC 2.6.1.40) and alanine-glyoxylate aminotransferase 2 (EC 2.6.1.44) were co-purified from rat liver as a single protein. The ratio of the twoExpand
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Analysis of cyclic feed intake in rats fed on a zinc-deficient diet and the level of dihydropyrimidinase (EC 3.5.2.2).
The body weight and feed intake of rats fed on a Zn-deficient diet for 28 d were reduced compared with those of control rats. The feed intakes of the Zn-deficient and control groups during the periodExpand
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Irreversible inhibition of D‐3‐aminoisobutyrate‐pyruvate aminotransferase by gabaculine
Gabaculine, 5‐amino‐l,3‐cyclohexadienylcarboxylate, is an analogue of GABA and a potent irreversible inhibitor of GABA aminotransferase. However, D‐3‐aminoisobutyrate‐pyruvate aminotransferase forExpand
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Role of dihydropyrimidine dehydrogenase in the uridine nucleotide metabolism in the rat liver.
The activity of dihydropyrimidine dehydrogenase, which is the rate-limiting enzyme in the catabolism of pyrimidine, in livers of 5-day-old rats increased 48 h after glucocorticoid injection. TheExpand
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Effect of dietary protein on pyrimidine-metabolizing enzymes in rats.
The effect of dietary protein on pyrimidine-metabolizing enzymes was studied in the rat. The activities of dihydropyrimidine dehydrogenase and beta-ureidopropionase in the livers of rats fed aExpand
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