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Amyotrophic lateral sclerosis
Clinical diagnosis and management of amyotrophic lateral sclerosis
Optimal treatment is based on symptom management and preservation of quality of life, provided in a multidisciplinary setting, and Riluzole remains the only effective drug, and extends the average survival of patients by 3–6 months.
Multiple measures of axonal excitability: A new approach in clinical testing
A new method is described that enables several measurements to be made on a motor nerve quickly and reproducibly, with minimal operator intervention, and makes it appropriate for routine clinical use.
Controversies and priorities in amyotrophic lateral sclerosis
Excitability of human axons
Chemotherapy‐induced peripheral neurotoxicity: A critical analysis
- Susanna B. Park, D. Goldstein, M. Kiernan
- Medicine, BiologyCA: a cancer journal for clinicians
- 1 November 2013
This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers.
Guillain-Barré syndrome: An update
Strength-duration properties of human peripheral nerve.
Weiss's formula, which relates threshold charge to stimulus duration, provided an accurate fit for the experimental data, and the study validated that, using it, relatively few experimental measurements were required to calculate the time constant.
Chronic inflammatory demyelinating polyradiculoneuropathy: from pathology to phenotype
- E. Mathey, Susanna B. Park, C. Lin
- Biology, MedicineJournal of Neurology, Neurosurgery & Psychiatry
- 12 February 2015
In this review, the roles of the cellular and humoral immune systems in the pathogenesis of CIDP will be discussed and delineation of clinical phenotypes and the underlying disease mechanisms might help guide diagnostic and individualised treatment strategies for CIDs.
Grey and White Matter Changes across the Amyotrophic Lateral Sclerosis-Frontotemporal Dementia Continuum
- P. Lillo, E. Mioshi, J. Burrell, M. Kiernan, J. Hodges, M. Hornberger
- PsychologyPloS one
- 29 August 2012
It is shown for the first time that FTD and ALS overlap in anterior cingulate, motor cortex and related white matter tract changes across the whole continuum, which will inform future diagnosis and target disease management across the continuum.