• Publications
  • Influence
Hepatitis B virus genotypes.
Eight genotypes of hepatitis B virus (A-H) are currently recognized, and subgenotypes have recently been described in four of these genotypes (A, B, C and F). The genotypes show a distinctExpand
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A unique segment of the hepatitis B virus group A genotype identified in isolates from South Africa.
The preS2/S genes of hepatitis B virus isolated from 29 acutely or chronically infected individuals in the Gauteng province of South Africa were sequenced. Phylogenetic analysis of these sequences inExpand
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Relationship of serological subtype, basic core promoter and precore mutations to genotypes/subgenotypes of hepatitis B virus
Using phylogenetic analysis and pairwise comparison of 670 complete hepatitis B virus (HBV) genomes, we demonstrated that nucleotide divergence greater than 7.5% can be used to separate strains intoExpand
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Hepatitis B virus x protein in the pathogenesis of hepatitis B virus‐induced hepatocellular carcinoma
  • M. Kew
  • Biology, Medicine
  • Journal of gastroenterology and hepatology
  • 1 January 2011
Currently available evidence supports a role for the hepatitis B virus (HBV) x gene and protein in the pathogenesis of HBV‐induced hepatocellular carcinoma (HCC). HBx gene is often included, andExpand
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Outbreake of Marburg virus disease in Johannesburg.
The first recognised outbreak of Marburg virus disease in Africa, and the first since the original epidemic in West Germany and Yugoslavia in 1967, occurred in South Africa in February 1975. TheExpand
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Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma.
BACKGROUND & AIMS The molecular pathogenesis of human hepatocellular carcinoma (HCC) is understood poorly. In some tumors, activation of the Wnt/beta-catenin pathway as a result of beta-catenin geneExpand
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Hepatitis B virus and human immunodeficiency virus co‐infection in sub‐Saharan Africa: a call for further investigation
Abstract: A growing body of evidence indicates that human immunodeficiency virus (HIV)‐positive individuals are more likely to be infected with hepatitis B virus (HBV) than HIV‐negative individuals,Expand
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Epidemiology of chronic hepatitis B virus infection, hepatocellular carcinoma, and hepatitis B virus-induced hepatocellular carcinoma.
  • M. Kew
  • Medicine
  • Pathologie-biologie
  • 1 August 2010
Approximately 360 million people worldwide are chronically infected with hepatitis B virus (HBV) and are at high risk of developing hepatocellular carcinoma (HCC). Chronic HBV infection is the mostExpand
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The core promoter of hepatitis B virus
The core promoter (CP) of hepatitis B virus (HBV) plays a central role in HBV replication and morphogenesis, directing the transcription of both species of 3.5 kb mRNA: pregenomic (pg) RNA andExpand
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High prevalence of 1762T 1764A mutations in the basic core promoter of hepatitis B virus isolated from black africans with hepatocellular carcinoma compared with asymptomatic carriers
The purpose of this study was to identify mutations in the basic core promoter and enhancer II region of the hepatitis B virus (HBV) that might cause the HBV e antigen (HBeAg)‐negative phenotype andExpand
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