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Why do many psychiatric disorders emerge during adolescence?
TLDR
The peak age of onset for many psychiatric disorders is adolescence, a time of remarkable physical and behavioural changes and answers to these questions might enable the understanding of mental health during adolescence. Expand
Maturation of Widely Distributed Brain Function Subserves Cognitive Development
TLDR
It is suggested that efficient top-down modulation of reflexive acts may not be fully developed until adulthood and evidence that maturation of function across widely distributed brain regions lays the groundwork for enhanced voluntary control of behavior during cognitive development is provided. Expand
Schizophrenia, “Just the Facts”: What we know in 2008 Part 1: Overview
TLDR
A body of seventy-seven representative major findings is compiled and group them in terms of their specific relevance to schizophrenia -- etiologies, pathophysiology, clinical manifestations, and treatments, and pose one or more critical questions with reference to each "fact", which might help better elucidate the meaning of that finding for the authors' understanding of schizophrenia. Expand
Developmental traumatology part II: brain development∗ ∗ See accompanying Editorial, in this issue.
TLDR
The overwhelming stress of maltreatment experiences in childhood is associated with adverse brain development, and brain volume robustly and positively correlated with age of onset of PTSD trauma and negatively correlated with duration of abuse. Expand
The psychosis high-risk state: a comprehensive state-of-the-art review.
TLDR
The relatively new field of HR research in psychosis has the potential to shed light on the development of major psychotic disorders and to alter their course and provides a rationale for service provision to those in need of help who could not previously access it. Expand
Schizophrenia, “just the facts” 4. Clinical features and conceptualization
TLDR
Heterogeneity in the etiopathology, symptomatology, and course of schizophrenia can be addressed by a dimensional approach to psychopathology, a clinical staging approach to illness course, and by elucidating endophenotypes and markers of illness progression, respectively. Expand
Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographically matched study
TLDR
Brain volumes positively correlated with age of onset of PTSD trauma and negatively correlated with duration of abuse, and gender x group effect demonstrated greater lateral ventricular volume increases in maltreated male subjects with PTSD than maltreated female subjects with flashbacks. Expand
Developmental traumatology part I: biological stress systems∗ ∗ See accompanying Editorial, in this issue.
TLDR
Urinary catecholamine and UFC concentrations showed positive correlations with duration of the PTSD trauma and severity of PTSD symptoms, suggesting that maltreatment experiences are associated with alterations of biological stress systems in maltreated children with PTSD. Expand
Decrease in caudate glutamatergic concentrations in pediatric obsessive-compulsive disorder patients taking paroxetine.
TLDR
Preliminary findings provide new evidence of Glx abnormalities in the caudate nucleus in pediatric OCD and suggest that paroxetine treatment may be mediated by a serotonergically modulated reduction in caudates glutamatergic concentrations. Expand
Schizophrenia, “Just the Facts” What we know in 2008. 2. Epidemiology and etiology
TLDR
This article critically review genetic and other epidemiological findings and discusses the insights they provide into the causes of schizophrenia and questions basic assumptions about the etiology and nature of schizophrenia appear critical to improving understanding about its causation. Expand
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