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Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor
It is hypothesized that cannabidiol would inhibit cannabinoid agonist activity through negative allosteric modulation of CB1 receptors through positive allosterics modulation ofCB1 receptors. Expand
Type 1 Cannabinoid Receptor Ligands Display Functional Selectivity in a Cell Culture Model of Striatal Medium Spiny Projection Neurons*
These data demonstrate that individual cannabinoids display functional selectivity at CB1 leading to activation of distinct signaling pathways, which may be exploited to maximize therapeutic efficacy. Expand
Effect of intraocular pressure on optic disc topography, electroretinography, and axonal loss in a chronic pressure-induced rat model of optic nerve damage.
Structural and functional changes in this model are best correlated to peak deltaIOP and not to duration of IOP elevation, suggesting the existence of an IOP-related damage threshold. Expand
Carbenoxolone inhibition of voltage-gated Ca channels and synaptic transmission in the retina.
We show that carbenoxolone, a drug used to block hemichannels in the retina to test the ephaptic model of horizontal cell inhibitory feedback, has strong inhibitory effects on voltage-gated CaExpand
Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol‐dimethylheptyl at the type 1 and type 2 cannabinoid receptors
We sought to understand why (−)‐cannabidiol (CBD) and (−)‐cannabidiol‐dimethylheptyl (CBD‐DMH) exhibit distinct pharmacology, despite near identical structures.
The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms.
Pimozide and mibefradil inhibit cell proliferation via different cytotoxic pathways and that in the case of pimozide, it is unlikely that this effect is mediated solely by T-channel inhibition. Expand
Model of endothelin-1-induced chronic optic neuropathy in rat.
Chronic administration of ET-1 to the rat optic nerve results in a time-dependent loss of RGCs and their axons without apparent change in optic disc topography. Expand
Cannabinoid receptor-mediated inhibition of calcium signaling in rat retinal ganglion cells.
Activation of CB(1)Rs in cultured RGCs inhibits HVA Ca(2+) channel currents, and data show that cannabinoids can modify the excitability of R GCs and could affect retinal output, implications for retinal signal processing. Expand
Calcium channels at the photoreceptor synapse.
  • S. Barnes, M. Kelly
  • Chemistry, Medicine
  • Advances in experimental medicine and biology
  • 2002
Ca2+ permeable cyclic nucleotide gated (CNG) channels appear to have supporting roles at the photoreceptor output synapse and may transduce NO signals from other cells by either directly permitting Ca2+ influx or by providing depolarizing influences that gate voltage dependent Ca2+, channels. Expand
Physical and functional interaction between CB1 cannabinoid receptors and β2‐adrenoceptors
Physical and functional interactions between the CB1 cannabinoid receptor and the β2‐adrenoceptor in a heterologous expression system and in primary human ocular cells are examined. Expand