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Acute and chronic acetaminophen use and renal disease: a case-control study using pharmacy and medical claims.
TLDR
Acute prescription-acquired APAP use was associated with renal disease, while chronic use was not, and further research accounting for over-the-counter AP AP use is warranted before the safety of chronic APAP consumption can be firmly established. Expand
The effect of food on the bioavailability of ibuprofen and flurbiprofen from sustained release formulations.
TLDR
Results indicate that despite a significant increase in peak plasma concentrations of both drugs with a meal, the bioavailability of flurbiprofen alone was enhanced, and qualitative changes in the plasma concentration versus time curves are primarily influenced by the nature of the formulation and the type of meal. Expand
Prescription-Acquired Acetaminophen Use and the Risk of Asthma in Adults: A Case-Control Study
TLDR
Chronic prescription-acquired acetaminophen use was associated with an increased risk of asthma, while recent use was not, and further epidemiologic research with completeacetaminophen exposure ascertainment and research on pathophysiologic mechanisms is needed to confirm these relationships. Expand
Pharmacokinetics and amoebicidal activity of (+-)-(E)-3-(4- methylsulphinylstyryl)-1,2,4-oxadiazole (BTI 2286E) and its sulphone metabolite (BTI 2571E) in the golden hamster, Mesocricetus auratus.
TLDR
The amoebicidal activity of both BTI 2286E and BTI 2571E was evaluated in the acute hamster hepatic model of amoEBiasis and their dose-response profiles were characterized. Expand
Pharmacokinetics of Flosequinan and its Sulphone Metabolite in Asian Indians
The pharmacokinetics of flosequinan, a peripheral vasodilator, and its active sulphone metabolite, flosequinoxan, were investigated in eleven Asian Indian male volunteers, in a phase 1 clinicalExpand