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Driving forces for changes in geographical distribution of Ixodes ricinus ticks in Europe
TLDR
Improved tick surveillance with harmonized approaches for comparison of data enabling the follow-up of trends at EU level will improve the messages on risk related to tick-borne diseases to policy makers, other stake holders and to the general public. Expand
Ixodes ricinus and Its Transmitted Pathogens in Urban and Peri-Urban Areas in Europe: New Hazards and Relevance for Public Health
TLDR
Understanding the ecology of ticks and their associations with hosts in a European urbanized environment is crucial to quantify parameters necessary for risk pre-assessment and identification of public health strategies for control and prevention of tick-borne diseases. Expand
Exposed and concealed antigens as vaccine targets for controlling ticks and tick‐borne diseases
TLDR
A third group of antigens has been distinguished that combines the properties of both exposed and concealed antIGens and offers the prospect of a broad‐spectrum vaccine effective against both adults and immature stages of a wide variety of tick species. Expand
Tick salivary compounds: their role in modulation of host defences and pathogen transmission
TLDR
Promotion of pathogen transmission by bioactive molecules in tick saliva was described as saliva-assisted transmission (SAT), and SAT candidates comprise compounds with anti-haemostatic, anti-inflammatory and immunomodulatory functions, but the molecular mechanisms by which they mediate pathogen Transmission are largely unknown. Expand
Babesia spp. in ticks and wildlife in different habitat types of Slovakia
TLDR
Findings suggest that I. ricinus and rodents play important roles in the epidemiology of zoonotic Babesia spp. Expand
Non-Hemagglutinating Flaviviruses: Molecular Mechanisms for the Emergence of New Strains via Adaptation to European Ticks
TLDR
It is proposed that the emergence of atypical Siberian HA-deficient TBEV strains in Europe is linked to their molecular adaptation to local ticks, driven by the selection of single mutations that change the virion surface thus enhancing receptor/fusion function essential for T BEV entry into the unfamiliar tick species. Expand
An Antivector Vaccine Protects against a Lethal Vector-Borne Pathogen
TLDR
The 64TRP vaccine demonstrates the potential to control vector-borne disease by interfering with pathogen transmission, apparently by mediating a local cutaneous inflammatory immune response at the tick-feeding site. Expand
The Essential Role of Tick Salivary Glands and Saliva in Tick Feeding and Pathogen Transmission
TLDR
During their long co-evolution with ticks and vertebrate hosts, microorganisms have indeed developed various strategies to exploit tick salivary molecules to ensure both acquisition by ticks and transmission, local infection and systemic dissemination within the vertebrate host. Expand
Effects of deer density on tick infestation of rodents and the hazard of tick-borne encephalitis. I: empirical assessment.
TLDR
The results suggest that the interactions between deer, rodents and ticks are much more complex on a local scale, supporting the possibility of a dilution effect for TBE. Expand
Tick-Borne Viruses and Biological Processes at the Tick-Host-Virus Interface
TLDR
Future research should be aimed at identification of the key tick salivary molecules promoting virus transmission, and a molecular description of tick-host-virus interactions and oftick-mediated skin immunomodulation that will enable the rationale design of anti-tick vaccines that protect against disease caused by tick-borne viruses. Expand
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