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Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
A hippocampal pyramidal neuron receives more than 10(4) excitatory glutamatergic synapses. Many of these synapses contain the molecular machinery for messenger RNA translation, suggesting that theExpand
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Intracellular and Trans-Synaptic Regulation of Glutamatergic Synaptogenesis by EphB Receptors
The majority of mature excitatory synapses in the CNS are found on dendritic spines and contain AMPA- and NMDA-type glutamate receptors apposed to presynaptic specializations. EphB receptor tyrosineExpand
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Cell adhesion molecules: signalling functions at the synapse
Many cell adhesion molecules are localized at synaptic sites in neuronal axons and dendrites. These molecules bridge pre- and postsynaptic specializations but do far more than simply provide aExpand
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EphB Receptors Couple Dendritic Filopodia Motility to Synapse Formation
Motile dendritic filopodial processes are thought to be precursors of spine synapses, but how motility relates to cell-surface cues required for axon-dendrite recognition and synaptogenesis remainsExpand
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EphB Controls NMDA Receptor Function and Synaptic Targeting in a Subunit-Specific Manner
Dynamic regulation of the localization and function of NMDA receptors (NMDARs) is critical for synaptic development and function. The composition and localization of NMDAR subunits at synapses areExpand
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Anti-NMDA Receptor Encephalitis in Psychiatry.
Anti-NMDA receptor encephalitis is an autoimmune disorder in which antibodies attack NMDA (N-methyl-D-aspartate)-type glutamate receptors at central neuronal synapses. Symptoms include a highlyExpand
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A Critical Period of Sleep for Development of Courtship Circuitry and Behavior in Drosophila
Sleep Tight, Fly Shortly after eclosion, young flies sleep a lot and are resistant to being woken. Several days later, the same flies sleep less and are more easily woken. Kayser et al. (p. 269) showExpand
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The emerging link between autoimmune disorders and neuropsychiatric disease.
Abnormal autoimmune activity has been implicated in a number of neuropsychiatric disorders. In this review, the authors discuss a newly recognized class of synaptic autoimmune encephalitides as wellExpand
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Sleep deprivation suppresses aggression in Drosophila
Sleep disturbances negatively impact numerous functions and have been linked to aggression and violence. However, a clear effect of sleep deprivation on aggressive behaviors remains unclear. We findExpand
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Psychiatric manifestations of paraneoplastic disorders.
Paraneoplastic disorders of the CNS result from immune responses to neuronal proteins expressed by tumors found elsewhere in the body. Limbic encephalitis, one of the most common manifestations ofExpand
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