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Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin?
Stratum corneum lipids are an important determinant for both water-retention function and permeability-barrier function in the stratum corneum. However, their major constituent, ceramides, have notExpand
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A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic
BACKGROUND Dihydrotestosterone is the main androgen causative of androgenetic alopecia, a psychologically and physically harmful condition warranting medical treatment. OBJECTIVE We sought toExpand
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The epidermal stem cell factor is over-expressed in lentigo senilis: implication for the mechanism of hyperpigmentation.
We previously reported that accentuated expression of the endothelin-1 (ET-1)/endothelin B receptor (ET(B)R) cascade is involved in the mechanism of hyperpigmentation in lentigo senilis (LS) lesions.Expand
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Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease.
OBJECTIVE Interleukin-18 (IL-18) is a proinflammatory cytokine that is involved in immunologically mediated tissue damage, but its bioactivity is regulated in vivo by its soluble decoy receptor,Expand
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Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus
The stratum corneum of the skin of patients with atopic dermatitis is highly susceptible to colonization by various bacteria, including Staphylococcus aureus. The defense system of the skin againstExpand
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The Japanese Version of Skindex‐16: A Brief Quality‐of‐Life Measure for Patients with Skin Diseases
A practical quality‐of‐life measure applicable to patients with skin diseases is necessary. Recently developed dermatological quality‐of‐life measures must be translated and adapted for use inExpand
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Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency?
Previously, we demonstrated that there is a marked reduction in the amount of ceramide in the stratum corneum of both lesional and nonlesional forearms in atopic dermatitis (AD), suggesting that anExpand
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Sphingosylphosphorylcholine is a Melanogenic Stimulator for Human Melanocytes.
As lysosphingolipids have multiple bio-modulator functions in various types of cells, we measured the biological effects of sphingosylphosphorylcholine (SPC) on cultured human melanocytes toExpand
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Efficacy and safety of ixekizumab treatment for Japanese patients with moderate to severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis: Results from a 52‐week,
Psoriasis, a chronic, immune‐mediated skin disease characterized by red, scaly plaques, affects approximately 0.3% of the population in Japan. The aim of this open‐label study was to evaluate theExpand
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Rupture of the pectoralis major. Report of 2 cases.
Two cases of rupture of the pectoralis major are reported, one caused by excessive tension and direct violence, while the other was a result of direct violence alone. The site of the rupture was atExpand
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