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Superoxide anion radical-triggered Ca2+ release from cardiac sarcoplasmic reticulum through ryanodine receptor Ca2+ channel.
For the first time, it is shown that O2- stimulates Ca2+ release from heavy SR vesicles and the importance of accessory proteins such as calmodulin in modulating the effect of O2-. Expand
Constrictor action of oxyhemoglobin in monkey and dog basilar arteries in vivo and in vitro.
Findings suggest that cerebral artery constriction caused by HbO2 in vivo and in vitro is associated mainly with the release of vasoconstrictor PGs, such as PGE2 and PGF2 alpha. Expand
Comparison of endothelium‐dependent responses of monkey cerebral and temporal arteries
- N. Toda, M. Kawakami, M. Yamazaki, T. Okamura
- Biology, Medicine
- British journal of pharmacology
- 1 April 1991
Heterogeneity in the endothelium‐dependency of several vasodilator responses in monkey intra‐ and extracranial arteries is clearly indicated, although the ability of these arteries to respond to A23187 and glyceryl trinitrate does not appear to differ. Expand
Suppression of the cerebral vasospastic actions of oxyhemoglobin by ascorbic acid.
It is concluded that incubation of oxyhemoglobin with ascorbic acid alters markedly the biological activity of Oxy-Hb; the vasoconstrictor activity is suppressed, and the ability to diminish vasodilator actions is minimized. Expand
Effects of in vitro and in vivo exposure to doxorubicin (adriamycin) on caffeine-induced Ca2+ release from sarcoplasmic reticulum and contractile protein function in 'chemically-skinned' rabbit…
Data from the present study are consistent with the view that doxorubicin acts in a similar manner to ryanodine and results in cardiomyopathy due to Ca2+-overload. Expand
Prevention by nicardipine of dog basilar artery spasm caused by oxyhemoglobin in vivo and in vitro.
Intravenous infusions of nicardipine in a dose insufficient to lower blood pressure prevented the generation of the basilar artery spasm provoked by oxyhemoglobin (oxyHb) injected intracisternally in… Expand
[Vasodilator actions of felodipine, a new Ca2+ entry blocker].
- M. Kawakami, K. Bian, N. Toda
- Chemistry, Medicine
- Nihon yakurigaku zasshi. Folia pharmacologica…
- 1 October 1989
It is suggested that felodipine is a potent, long-acting Ca2+ entry blocker with characteristics such as a greater action on cerebral arteries and mesenteric veins than coronary and Mesenteric arteries. Expand