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Microtubules and resistance to tubulin-binding agents
Nature Reviews Cancer 10, 194–204 (2010) On page 202 of this article, extracellular matrix transforming growth factor-β1 (TGFβ1), should have read extracellular matrix transforming growth factor-βExpand
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Metronomic chemotherapy: new rationale for new directions
Tumor angiogenesis is recognized as a major therapeutic target in the fight against cancer. The key involvement of angiogenesis in tumor growth and metastasis has started to redefine chemotherapy andExpand
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Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells
The pro-apoptotic protein, Bax, has been reported to translocate from cytosol to mitochondria following exposure of cells to apoptotic stresses including cytokine withdrawal and treatment withExpand
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Integrative analysis of RUNX1 downstream pathways and target genes
BackgroundThe RUNX1 transcription factor gene is frequently mutated in sporadic myeloid and lymphoid leukemia through translocation, point mutation or amplification. It is also responsible for aExpand
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Movers and shakers: cell cytoskeleton in cancer metastasis
Metastasis is responsible for the greatest number of cancer deaths. Metastatic disease, or the movement of cancer cells from one site to another, is a complex process requiring dramatic remodellingExpand
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Microtubules and Their Role in Cellular Stress in Cancer
Microtubules are highly dynamic structures, which consist of α- and β-tubulin heterodimers, and are involved in cell movement, intracellular trafficking, and mitosis. In the context of cancer, theExpand
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Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes.
The treatment of advanced ovarian cancer with taxol is hindered by the development of drug resistance. The cellular target for taxol is the microtubule that is stabilized by the drug. TaxolExpand
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Microtubules: a dynamic target in cancer therapy.
The tubulin/microtubule system is an important target for anticancer therapy. Two of the most clinically valuable groups of these agents are the vinca alkaloids and taxanes. In recent years, newExpand
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Tissue-specific Tropomyosin Isoform Composition
Four distinct genes encode tropomyosin (Tm) proteins, integral components of the actin microfilament system. In non-muscle cells, over 40 Tm isoforms are derived using alternative splicing. DistinctExpand
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