The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking.
- M. Kauppi, A. Simonsen, V. Olkkonen
- BiologyJournal of Cell Science
- 1 March 2002
Results suggest that Rab22a may regulate the dynamic interactions of endosomal compartments and it may be involved in the communication between the biosynthetic and early endocytic pathways.
Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation
- Ashley P Ng, M. Kauppi, W. Alexander
- BiologyProceedings of the National Academy of Sciences
- 19 March 2014
It is shown TPO signaling via Mpl is not required in megakaryocytes for their expansion, maturation, or platelet production; its key role in control of platelet number is via generation and stimulation of the bipotential megakARYocyte precursors.
Munc18-2, a Functional Partner of Syntaxin 3, Controls Apical Membrane Trafficking in Epithelial Cells*
- K. Riento, M. Kauppi, S. Keränen, V. Olkkonen
- BiologyJournal of Biological Chemistry
- 5 May 2000
It is suggested that Munc18-2 function in apical membrane trafficking involves aspects independent of the syntaxin 3 interaction, which implies that the Sec1-related proteins bind to syntaxin family t-SNAREs with high affinity.
Analysis of the Munc18b-Syntaxin Binding Interface
- M. Kauppi, G. Wohlfahrt, V. Olkkonen
- BiologyJournal of Biological Chemistry
- 15 November 2002
Over-expression of Munc18b S48D inhibited transport of influenza hemagglutinin to the apical surface of Madin-Darby canine kidney II cells, which express syntaxin 2 abundantly, but not of Caco-2 cells, in which syntaxin 3 is the major apical target SNARE (soluble NSF (N-ethylmaleimide sensitive factor) attachment protein receptors).
Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans
- Jarny Choi, T. Baldwin, C. D. Graaf
- Biology, MedicineNucleic Acids Res.
- 5 November 2018
Haemopedia, a database of gene-expression profiles from a broad spectrum of haematopoietic cells, is updated to include RNA-seq gene- expression data from both mice and humans, and the ability to compare gene expression across data sets and species is added.
Haemopedia: An Expression Atlas of Murine Hematopoietic Cells
- C. D. de Graaf, Jarny Choi, D. Hilton
- BiologyStem Cell Reports
- 4 August 2016
Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis.
- Stanley C. Lee, Sarah E. Miller, W. Alexander
- Biology, MedicineBlood
- 9 July 2015
The role ofPRC2 in hematopoiesis is investigated by conditional deletion of suppressor of zeste 12 protein homolog (Suz12), a core component of PRC2, revealing a multifaceted role, with divergent dose-dependent effects in HSC and distinct roles in maturing blood cells.
Regulation of hematopoietic stem cells by their mature progeny
- C. D. de Graaf, M. Kauppi, D. Hilton
- BiologyProceedings of the National Academy of Sciences
- 29 November 2010
It is demonstrated that the megakaryocytosis and increased platelet mass in mice with mutations in the Myb or p300 genes causes reduced circulating TPO concentration and TPO starvation of the stem-cell compartment, which is exacerbated because these cells additionally exhibit impaired responsiveness to TPO.
A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini.
- Patrick P. L. Lam, K. Hyvärinen, V. Olkkonen
- BiologyMolecular Biology of the Cell
- 1 July 2007
Cab45b is identified as a novel protein factor involved in the exocytosis of zymogens by pancreatic acini and antibodies against Cab45b are shown to inhibit in a specific and dose-dependent manner the Ca(2+)-induced amylase release from streptolysin-O-permeabilized acini.
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene
- W. Alexander, E. Viney, D. Hilton
- Biology, MedicineProceedings of the National Academy of Sciences
- 31 October 2006
An N-ethyl-N-nitrosourea mutagenesis screen in mice was performed to isolate regulators of circulating platelet number. We report here recessive thrombocytopenia and kidney disease in plt1 mice,…
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