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Gastric emptying and release of incretin hormones after glucose ingestion in humans.
This study investigated in eight healthy male volunteers (a) the gastric emptying pattern of 50 and 100 grams of glucose; (b) its relation to the phase of interdigestive motility (phase I or II)… Expand
Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans.
- J. Schirra, K. Sturm, P. Leicht, R. Arnold, B. Göke, M. Katschinski
- The Journal of clinical investigation
- 1 April 1998
The gastrointestinal hormone, glucagon-like peptide-1(7-36)amide (GLP-1) is released after a meal. The potency of synthetic GLP-1 in stimulating insulin secretion and in inhibiting glucagon secretion… Expand
Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans
Background: Exogenous use of the intestinal hormone glucagon-like peptide 1 (GLP-1) lowers glycaemia by stimulation of insulin, inhibition of glucagon, and delay of gastric emptying. Aims: To assess… Expand
Differential effects of subcutaneous GLP-1 on gastric emptying, antroduodenal motility, and pancreatic function in men.
- J. Schirra, P. Kuwert, +4 authors M. Katschinski
- Proceedings of the Association of American…
In this study of eight healthy male volunteers, we investigated the effects of graded doses of subcutaneous glucagon like peptide-1(7-36)amide (GLP-1) on: 1) the gastric emptying pattern of a mixed… Expand
Effects of glucagon-like peptide-1(7-36)amide on antro-pyloro-duodenal motility in the interdigestive state and with duodenal lipid perfusion in humans
BACKGROUND Glucagon-like peptide-1(7-36)amide (GLP-1) is a gut hormone released postprandially. Synthetic GLP-1 strongly inhibits gastric emptying in healthy subjects and in patients with diabetes… Expand
GLP-1-induced alterations in the glucose-stimulated insulin secretory dose-response curve.
- A. Brandt, M. Katschinski, R. Arnold, K. Polonsky, B. Göke, M. Byrne
- Biology, Medicine
- American journal of physiology. Endocrinology and…
- 1 August 2001
The present study was undertaken to establish in normal volunteers the alterations in beta-cell responsiveness to glucose associated with a constant infusion of glucagon-like peptide-1 (GLP-1) or a… Expand
Cephalic stimulation of gastrointestinal secretory and motor responses in humans.
The present study was designed (a) to investigate the cephalic phase of gastropancreatic secretion, antroduodenal motility, and regulatory peptide release in six healthy young men and (b) to assess… Expand
Mechanisms of the antidiabetic action of subcutaneous glucagon-like peptide-1(7-36)amide in non-insulin dependent diabetes mellitus.
Twelve patients with non-insulin dependent diabetes mellitus (NIDDM) under secondary failure to sulfonylureas were studied to evaluate the effects of subcutaneous glucagon-like peptide-1(7-36)amide… Expand
GLP‐1 regulates gastroduodenal motility involving cholinergic pathways
- J. Schirra, M. Nicolaus, H. Woerle, C. Struckmeier, M. Katschinski, B. Göke
- Neurogastroenterology and motility : the official…
- 1 June 2009
Abstract The gut‐born incretin hormone glucagon‐like peptide‐1 (GLP‐1) delays gastric emptying. To elucidate the mechanisms by which GLP‐1 affects gastroduodenal motility and glycaemia, we studied… Expand
Myoelectric and manometric patterns of human rectosigmoid colon in irritable bowel syndrome and diverticulosis.
- M. Katschinski, P. Lederer, A. Ellermann, R. Ganzleben, G. Lux, R. Arnold
- Scandinavian journal of gastroenterology
- 1 July 1990
Rectosigmoid electric control activity and intraluminal pressure were measured in the fasting state and after a standard 3040-kJ meal in irritable bowel syndrome (IBS) patients (n = 41),… Expand