• Publications
  • Influence
Gastric emptying and release of incretin hormones after glucose ingestion in humans.
This study investigated in eight healthy male volunteers (a) the gastric emptying pattern of 50 and 100 grams of glucose; (b) its relation to the phase of interdigestive motility (phase I or II)Expand
  • 400
  • 22
  • PDF
Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans.
The gastrointestinal hormone, glucagon-like peptide-1(7-36)amide (GLP-1) is released after a meal. The potency of synthetic GLP-1 in stimulating insulin secretion and in inhibiting glucagon secretionExpand
  • 235
  • 13
  • PDF
Endogenous glucagon-like peptide 1 controls endocrine pancreatic secretion and antro-pyloro-duodenal motility in humans
Background: Exogenous use of the intestinal hormone glucagon-like peptide 1 (GLP-1) lowers glycaemia by stimulation of insulin, inhibition of glucagon, and delay of gastric emptying. Aims: To assessExpand
  • 243
  • 11
  • PDF
Differential effects of subcutaneous GLP-1 on gastric emptying, antroduodenal motility, and pancreatic function in men.
In this study of eight healthy male volunteers, we investigated the effects of graded doses of subcutaneous glucagon like peptide-1(7-36)amide (GLP-1) on: 1) the gastric emptying pattern of a mixedExpand
  • 106
  • 9
Effects of glucagon-like peptide-1(7-36)amide on antro-pyloro-duodenal motility in the interdigestive state and with duodenal lipid perfusion in humans
BACKGROUND Glucagon-like peptide-1(7-36)amide (GLP-1) is a gut hormone released postprandially. Synthetic GLP-1 strongly inhibits gastric emptying in healthy subjects and in patients with diabetesExpand
  • 126
  • 5
  • PDF
GLP-1-induced alterations in the glucose-stimulated insulin secretory dose-response curve.
The present study was undertaken to establish in normal volunteers the alterations in beta-cell responsiveness to glucose associated with a constant infusion of glucagon-like peptide-1 (GLP-1) or aExpand
  • 28
  • 4
  • PDF
Cephalic stimulation of gastrointestinal secretory and motor responses in humans.
The present study was designed (a) to investigate the cephalic phase of gastropancreatic secretion, antroduodenal motility, and regulatory peptide release in six healthy young men and (b) to assessExpand
  • 97
  • 3
Mechanisms of the antidiabetic action of subcutaneous glucagon-like peptide-1(7-36)amide in non-insulin dependent diabetes mellitus.
Twelve patients with non-insulin dependent diabetes mellitus (NIDDM) under secondary failure to sulfonylureas were studied to evaluate the effects of subcutaneous glucagon-like peptide-1(7-36)amideExpand
  • 68
  • 3
  • PDF
GLP‐1 regulates gastroduodenal motility involving cholinergic pathways
Abstract  The gut‐born incretin hormone glucagon‐like peptide‐1 (GLP‐1) delays gastric emptying. To elucidate the mechanisms by which GLP‐1 affects gastroduodenal motility and glycaemia, we studiedExpand
  • 63
  • 3
Myoelectric and manometric patterns of human rectosigmoid colon in irritable bowel syndrome and diverticulosis.
Rectosigmoid electric control activity and intraluminal pressure were measured in the fasting state and after a standard 3040-kJ meal in irritable bowel syndrome (IBS) patients (n = 41),Expand
  • 51
  • 3