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Sex hormone-regulated renal transport of perfluorooctanoic acid.
Multiple regression analysis suggests that the change in the CL(R) of PFOA is, at least in part, due to altered expression of OAT2 and OAT3, which was significantly reduced by probenecid. Expand
Comparison of the elimination between perfluorinated fatty acids with different carbon chain length in rats.
PFCAs are distinguished by their carbon chain length by a renal excretion system, which is regulated by testosterone, and sex-related difference in urinary elimination of PFOA was abolished when male rats had been castrated. Expand
Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix–loop–helix transcription factors and cell cycle in neural stem cells
Treatment with DHA under differentiation conditions without basic fibroblast growth factor increases Tuj-1 and MAP2 positive cells in NSCs and decreases the percentage of S-phase cells, which correlated with prolonged expression of cyclin-dependent kinase inhibitor p27(kip1), suggesting that DHA enhances neuronal differentiation of NSCS, in part, by controlling the bHLH transcription factors and promoting cell cycle exit. Expand
Rat Organic Anion Transporter 3 and Organic Anion Transporting Polypeptide 1 Mediate Perfluorooctanoic Acid Transport
The mechanism by which perfluorooctanoic acid (PFOA) is transported in the kidney was studied in rats. We hypothesized that some transporters that are expressed in the basolateral and/or brush borderExpand
Green tea catechins prevent cognitive deficits caused by Abeta1-40 in rats.
It is suggested that long-term administration of green tea catechins provides effective prophylactic benefits against Abeta-induced cognitive impairment by increasing antioxidative defenses. Expand
Induction by perfluorinated fatty acids with different carbon chain length of peroxisomal beta-oxidation in the liver of rats.
Different potency of the induction of peroxisomal beta-oxidation was compared between perfluorinated fatty acids (PFCAs) with different carbon chain lengths in the liver of male and female rats to indicate that difference in accumulation between PFCAs in the Liver was responsible for the different potency. Expand
Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice.
Results strongly suggested that orally administered theobromine acted as a PDE inhibitor in the brain, and it augmented the cAMP/CREB/BDNF pathways and motor learning in mice. Expand
Long-term administration of green tea catechins improves spatial cognition learning ability in rats.
Rats administered PE had improved reference and working memory-related learning ability and had lower hippocampus reactive oxygen species concentrations than controls, suggesting that this improvement in spatial cognitive learning ability is due to the antioxidative activity of green tea catechins. Expand
Proliferation of neuronal progenitor cells and neuronal differentiation in the hypothalamus are enhanced in heat-acclimated rats
It is suggested that heat exposure facilitates proliferation of neuronal progenitor cells in the hypothalamus and promotes differentiation to neurons, which might have certain relation to establishing long-term heat acclimation in rats. Expand
Direct exposure to mild heat promotes proliferation and neuronal differentiation of neural stem/progenitor cells in vitro
Mild heat exposure increases NSC/NPC proliferation, possibly through activation of the Akt pathway, and also enhances neuronal differentiation in rats, suggesting heat-induced neurogenesis could also be an effective therapeutic strategy for neurodegenerative diseases. Expand