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Local communication on and within bone controls bone remodeling.
The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?
- F. Genovese, A. Manresa, D. Leeming, M. Karsdal, P. Boor
- Biology, MedicineFibrogenesis & tissue repair
- 28 March 2014
The use of the protein fingerprint technology, that identifies neo-epitopes of ECM proteins generated by proteolytic cleavage by proteases or other post-translational modifications, might identify such novel biomarkers of renal fibrosis.
An update on biomarkers of bone turnover and their utility in biomedical research and clinical practice
- D. Leeming, P. Alexandersen, M. Karsdal, P. Qvist, S. Schaller, L. Tankó
- Medicine, BiologyEuropean Journal of Clinical Pharmacology
- 16 August 2006
An update on biomarkers of bone turnover is given to give an overview of their applications in epidemiological and clinical research and suggests that biochemical markers may provide information on bone age that may have indirectly relates to bone quality.
Matrix Metalloproteinase-dependent Activation of Latent Transforming Growth Factor-β Controls the Conversion of Osteoblasts into Osteocytes by Blocking Osteoblast Apoptosis*
- M. Karsdal, L. Larsen, N. Foged
- Biology, MedicineThe Journal of Biological Chemistry
- 15 November 2002
It is suggested that MMP-activated TGF-β maintains osteoblast survival during trans-differentiation into osteocytes by a p44/42-dependent pathway.
Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use.
Characterization of metalloprotease cleavage products of human articular cartilage.
Characterization of these cartilage matrix peptides may help in the development of pharmacodynamic biomarkers of cartilage degradation, and also may contribute to an understanding of the bioactive peptides important in chondrocyte signaling.
Are Nonresorbing Osteoclasts Sources of Bone Anabolic Activity?
- M. Karsdal, T. Martin, J. Bollerslev, C. Christiansen, K. Henriksen
- BiologyJournal of bone and mineral research : the…
- 1 April 2007
The balance between bone resorption and bone formation is considered, reviewing novel data that have shown that this principle is more complex than originally thought and highlighting the distinct possibility that osteoclast function can be divided into two more or less separate functions, namely bone resOrption and stimulation of bone formation.
Characterization of osteoclasts derived from CD14+ monocytes isolated from peripheral blood
- M. Sørensen, K. Henriksen, M. Karsdal
- Biology, MedicineJournal of Bone and Mineral Metabolism
- 26 December 2006
The response to known bone resorption inhibitors was measured, and it was found that the osteoclasts were sensitive to these and thereby provided a robust and valid method for interpretation of the effect of antiresorptive compounds.
ADAPT: An Algorithm Incorporating PRO‐C3 Accurately Identifies Patients With NAFLD and Advanced Fibrosis
A PRO‐C3‐based score (ADAPT) accurately identifies patients with NAFLD and advanced fibrosis and is superior to APRI, FIB‐4, and NFS in most comparisons.
Novel insights into the function and dynamics of extracellular matrix in liver fibrosis.
- M. Karsdal, T. Manon-Jensen, D. Schuppan
- BiologyAmerican journal of physiology. Gastrointestinal…
- 15 May 2015
The aims of this review are to explore key structural and functional components of the ECM as exemplified by monogenetic disorders leading to severe pathologies, and discuss selected pathological posttranslational modifications of ECM proteins resulting in altered functional (signaling) properties from the original structural proteins.