• Publications
  • Influence
Local communication on and within bone controls bone remodeling.
Bone remodeling is required for healthy calcium homeostasis and for repair of damage occurring with stress and age. Osteoclasts resorb bone and osteoblasts form bone. These processes normally occurExpand
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Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use.
Osteoarthritis (OA) is a heterogeneous disorder. The goals of this review are (1) To stimulate use of standardized nomenclature for OA that could serve as building blocks for describing OA andExpand
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The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?
Interstitial fibrosis is the common endpoint of end-stage chronic kidney disease (CKD) leading to kidney failure. The clinical course of many renal diseases, and thereby of CKD, is highly variable.Expand
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Characterization of metalloprotease cleavage products of human articular cartilage.
OBJECTIVE To identify, characterize, and compare proteolysis peptide products generated by metalloprotease digests of human articular cartilage. METHODS Human articular cartilage was digested byExpand
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Matrix Metalloproteinase-dependent Activation of Latent Transforming Growth Factor-β Controls the Conversion of Osteoblasts into Osteocytes by Blocking Osteoblast Apoptosis*
Upon termination of bone matrix synthesis, osteoblasts either undergo apoptosis or differentiate into osteocytes or bone lining cells. In this study, we investigated the role of matrixExpand
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Are Nonresorbing Osteoclasts Sources of Bone Anabolic Activity?
Some osteopetrotic mutations lead to low resorption, increased numbers of osteoclasts, and increased bone formation, whereas other osteopetrotic mutations lead to low resorption, low numbers ofExpand
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Characterization of osteoclasts derived from CD14+ monocytes isolated from peripheral blood
Bone resorption is solely mediated by osteoclasts. Therefore, a pure osteoclast population is of high interest for the investigation of biological aspects of the osteoclasts, such as the directExpand
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The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?
Osteoarthritis (OA) is the most common form of arthritic disease, and a major cause of disability and impaired quality of life in the elderly. OA is a complex disease of the entire joint, affectingExpand
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Biglycan and fibromodulin have essential roles in regulating chondrogenesis and extracellular matrix turnover in temporomandibular joint osteoarthritis.
The temporomandibular joint is critical for jaw movements and allows for mastication, digestion of food, and speech. Temporomandibular joint osteoarthritis is a degenerative disease that is marked byExpand
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Transforming Growth Factor-β Controls Human Osteoclastogenesis through the p38 MAPK and Regulation of RANK Expression*
Although RANK-L is essential for osteoclast formation, factors such as transforming growth factor-β (TGF-β) are potent modulators of osteoclastogenic stimuli. To systematically investigate the roleExpand
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