Depletion of definitive gut endoderm in Sox17-null mutant mice.
- M. Kanai-Azuma, Yoshiakira Kanai, Y. Hayashi
- BiologyDevelopment
- 15 May 2002
These findings indicate an important role of Sox17 in endoderm development in the mouse, highlighting the idea that the molecular mechanism for endODerm formation is likely to be conserved among vertebrates.
Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis
- Y. Kanai, M. Kanai-Azuma, K. Yazaki
- BiologyJournal of Cell Biology
- 1 May 1996
Findings suggest that Sox17 may function as a transcriptional activator in the premeiotic germ cells, and that a splicing switch into t-Sox17 may lead to the loss of its function in the postmeiotics germ cells.
Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos.
- Youhei Sakamoto, K. Hara, Yoshiakira Kanai
- BiologyBiochemical and Biophysical Research…
- 31 August 2007
Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice
- T. Matsui, M. Kanai-Azuma, Yoshiakira Kanai
- Biology, MedicineJournal of Cell Science
- 1 September 2006
In vitro angiogenesis assays showed that the Sox17+/--Sox18-/- endothelial cells were defective in endothelial sprouting and remodeling of the vasculature in a phenotype-dependent manner, indicating that Sox17 and Sox18, and possibly all three SoxF genes, are cooperatively involved in mammalian vascular development.
A critical time window of Sry action in gonadal sex determination in mice
- R. Hiramatsu, Shogo Matoba, Yoshiakira Kanai
- BiologyDevelopment
- 1 January 2009
The results indicate the overarching importance of Sry action in the initial 6-hour phase for the female-to-male switching of FGF9/WNT4 signaling patterns.
Early endoderm development in vertebrates: lineage differentiation and morphogenetic function.
- P. Tam, M. Kanai-Azuma, Yoshiakira Kanai
- BiologyCurrent Opinion in Genetics and Development
- 1 August 2003
Maternal‐effect gene Ces5/Ooep/Moep19/Floped is essential for oocyte cytoplasmic lattice formation and embryonic development at the maternal‐zygotic stage transition
- F. Tashiro, M. Kanai-Azuma, J. Miyazaki
- BiologyGenes to Cells
- 1 August 2010
Analysis showed that CES5/OOEP was directly associated with the CPLs, which have long been predicted to function as a storage form for components that are maternally contributed to the early embryo.
The Ras Target AF-6 is a Substrate of the Fam Deubiquitinating Enzyme
- S. Taya, Takaharu G. Yamamoto, K. Kaibuchi
- BiologyJournal of Cell Biology
- 24 August 1998
It was found that Fam accumulated at the cell–cell contact sites of MDCKII cells, but not at free ends of plasma membranes, suggesting that the deubiquitinating activity of the fat facets product plays a critical role in controlling the cell fate.
Identification of Sox17 as a Transcription Factor That Regulates Oligodendrocyte Development
Findings support important roles for Sox17 in controlling both oligodendrocyte progenitor cell cycle exit and differentiation.
Syntaxin 1B, but Not Syntaxin 1A, Is Necessary for the Regulation of Synaptic Vesicle Exocytosis and of the Readily Releasable Pool at Central Synapses
- T. Mishima, T. Fujiwara, Masumi Sanada, T. Kofuji, M. Kanai-Azuma, K. Akagawa
- BiologyPLoS ONE
- 28 February 2014
Although STx1A and 1B share a basic function as neuronal t-SNAREs, STX1B but not STX 1A is necessary for the regulation of spontaneous and evoked synaptic vesicle exocytosis in fast transmission.
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