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Human health effects of air pollution.
TLDR
Air pollution has both acute and chronic effects on human health, affecting a number of different systems and organs, and ranges from minor upper respiratory irritation to chronic respiratory and heart disease, lung cancer, acute respiratory infections in children and chronic bronchitis in adults. Expand
Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action
TLDR
Phenolic acids exert a direct antiproliferative action, evident at low concentrations, comparable with those found in biological fluids after ingestion of foods rich in phenolic acids. Expand
Resveratrol exerts its antiproliferative effect on HepG2 hepatocellular carcinoma cells, by inducing cell cycle arrest, and NOS activation.
TLDR
The results indicate that the stilbene inhibits potently cell proliferation, reduces the production of reactive oxygen species and induces apoptosis, through cell cycle arrest in G1 and G2/M phases, and modulates the NO/NOS system, by increasing iNOS and eNOS expression, NOS activity and NO production. Expand
A new automated method for the determination of the Total Antioxidant Capacity (TAC) of human plasma, based on the crocin bleaching assay
TLDR
An automated assay to calculate the antioxidant capacity of plasma after a subtraction of all interference deriving from endogenous and/or exogenous metabolites is presented, which can be used as a useful indicator of the antioxidant value of foods and beverages in the daily diet. Expand
Estrogen anti‐inflammatory activity on human monocytes is mediated through cross‐talk between estrogen receptor ERα36 and GPR30/GPER1
TLDR
The expression of estrogen receptors is assessed and it is reported that the only estrogen receptors expressed are estrogen receptor‐α 36‐kDa splice variant and G‐protein coupled receptor 30/G‐protein estrogen receptor 1, in a sex‐independent manner. Expand
Adipocytes as Immune Cells: Differential Expression of TWEAK, BAFF, and APRIL and Their Receptors (Fn14, BAFF-R, TACI, and BCMA) at Different Stages of Normal and Pathological Adipose Tissue
TLDR
The data integrate BAFF, APRIL, and TWEAK and their receptors BCMA, TACI, and Fn14 as novel potential mediators of adipogenesis, in addition to their specific role in immunity, and define immature and mature adipocytes as source of immune mediators. Expand
ERα36, a new variant of the ERα is expressed in triple negative breast carcinomas and has a specific transcriptomic signature in breast cancer cell lines
TLDR
An early (direct) transcriptional signature of the receptor activation is revealed, related to immune system processes and T-cell differentiation, RNA biosynthesis, regulation of metabolism, VEGF signaling and regulation of the cell cycle, with a down-regulation of CREB, NFκB and STATs transcription factors. Expand
Adipose Tissue-Derived Mesenchymal Cells Support Skin Reepithelialization through Secretion of KGF-1 and PDGF-BB: Comparison with Dermal Fibroblasts
TLDR
Evidence is provided that ADMCs can serve as supportive cells for primary keratinocyte cultures because of their abundance and the great cell yield achieved during ADMC isolation, and they represent an interesting cell source, with potential aspects for clinical use. Expand
Membrane androgen receptor activation induces apoptotic regression of human prostate cancer cells in vitro and in vivo.
TLDR
Evidence is provided that activation of mAR by nonpermeable, BSA-coupled testosterone results in inhibition of L NCaP cell growth and induction in LNCaP cells of both apoptosis and the proapoptotic Fas protein, suggesting that activators of m AR may represent a new class of antitumoral agents of prostate cancer. Expand
Quercetin accumulates in nuclear structures and triggers specific gene expression in epithelial cells.
TLDR
Evidence is presented that nonconjugated quercetin enters cells possibly via organic anion transporter polypeptides and quickly accumulates in the nucleus where it concentrates at distinct foci, and that the flavonol modifies the transcription and/or activity of numerous transcription factors. Expand
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