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p13suc1 suppresses the catalytic function of p34cdc2 kinase for intermediate filament proteins, in vitro.
It appears that p13suc1 has a selective effect on the catalytic activity of p34cdc2 kinase for these filament proteins, especially vimentin and desmin.
Microtubule destabilization by cdc2/H1 histone kinase: phosphorylation of a "pro-rich region" in the microtubule-binding domain of MAP-4.
The phosphorylation of the Pro-rich region of MAP-4 and the suppression of its assembly-promoting activity by cdc2/H1 histone kinase are described and may cause disassembly of the interphase microtubular network at the end of the G2 phase of the cell cycle.
A point mutation in C-terminal region of cdc2 kinase causes a G2-phase arrest in a mouse temperature-sensitive FM3A cell mutant.
A mouse temperature-sensitive mutant for cell growth, tsFT210, was characterized, and as a result, the proline of wild-type cdc2 kinase at the 272 amino acid residues from N-terminal methionine changed to serine.
The difference in murine CDC2 kinase activity between cytoplasmic and nuclear fractions during the cell cycle.
The mouse analog of yeast CDC2+ kinase was detected in the cytoplasmic and nuclear fractions of cultured mouse FM3A cells and its activity increased in the G2/M phase and the amount of the enzyme remained almost constant during the cell cycle in both the nuclear and cytop lasmic fractions.
cdc2 kinase phosphorylation of desmin at three serine/threonine residues in the amino-terminal head domain.
Phosphorylation of desmin filament by cdc2 kinase induced a transition toward the depolymerized state of the filament. Sequence analysis of purified phosphopeptides derived from cdc2
In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinase.
The possibility that the function of RB protein is regulated by CDC2 kinase is suggested, after heLa cell extracts immunoprecipitated with anti-RB antiserum as well as RB proteins expressed in E. coli cells were shown to be phosphorylated by this kinase in vitro.
Non-cyclic AMP-dependent, positive inotropic cyclodepsipeptides with negative chronotropy.
  • A. Tsunoo, M. Kamijo
  • Medicine, Chemistry
    The Journal of pharmacology and experimental…
  • 1 September 1999
The results suggest that these CDPs produce both non-cyclic AMP-dependent positive inotropic and negative chronotropic effects.
Roseocardin, a novel cardiotonic cyclodepsipeptide from Trichothecium roseum TT103.
A new cyclodepsipeptide, designated roseocardin, was isolated from the culture broth of Trichothecium roseum TT103 and showed positive inotropic effects on rat heart muscles.
Preference of human cdc2 kinase for peptide substrate.
Human cyclin B1-bound cdc2 kinase phosphorylated the threonine residue in the sequence -Thr-Pro-Lys- Lys-Ala- but hardly phosphorylation it in the sequences - Thr- pro-ala-pro- lysine residues, as found in p53 protein.