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Ancestral proportions and admixture dynamics in geographically defined African Americans living in South Carolina.
The results of this study indicate, in accordance with previous historical, cultural, and anthropological evidence, a very low level of European admixture in the Gullah Sea Islanders, and a continuous gene flow model of admixture could explain the observed pattern of genetic structure.
Population structure in admixed populations: effect of admixture dynamics on the pattern of linkage disequilibrium.
It is demonstrated that by conditioning on parental admixture, populations with a CGF history of admixture not only are appropriate for admixture mapping but also have greater power for detection of linkage disequilibrium over large chromosomal regions than do populations that have experienced a pattern of admixtures more similar to the HI model, if methods are employed that detect and adjust for disequ equilibrium caused by continuous admixture.
DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease.
The data indicate that both polymorphisms synergistically contribute to the CHD risk in this sample and that this genetic risk is independent of the conventional plasma lipid profile.
Caucasian genes in American blacks: new data.
The homogeneity of locus-specific estimates of admixture indicates that these loci are appropriate for studying the proportion of black genes in any admixed population involving African admixture and the advantages of employing such loci for genetic-epidemiologic studies in U.S. blacks is discussed.
Ethnic variation in vitamin D-binding protein (GC): a review of isoelectric focusing studies in human populations
The anthropologic significance of the GC locus has been enhanced further by detecting additional unique GC variants which provide useful information about evolutionary links between different populations.
Genetic polymorphism of paraoxonase and the risk of coronary heart disease.
- D. Sanghera, N. Saha, C. Aston, M. Kamboh
- BiologyArteriosclerosis, thrombosis, and vascular…
- 1 June 1997
Data indicate that a common polymorphism in the PON gene is an independent risk factor for CHD in populations with white ancestry.
The codon 55 polymorphism in the paraoxonase 1 gene is not associated with the risk of coronary heart disease in Asian Indians and Chinese.
Two DNA polymorphisms in the lipoprotein lipase gene and their associations with factors related to cardiovascular disease.
Whether the two DNA polymorphisms showed comparable gene frequencies between diabetics and non-diabetics, and between the two ethnic groups, have significant impact in determining interindividual differences in plasma levels of total cholesterol, HDL-ch cholesterol, LDL-cholesterol, triglycerides, fasting glucose, and fasting insulin is estimated.
Genetic studies of human apolipoproteins. VI. Common polymorphism of apolipoprotein E in blacks.
Using isoelectric focusing and immunoblotting, apolipoprotein E phenotypes and gene frequencies in a large number of individuals of black ancestry from the U.S. and Nigeria are determined.
Genetic Variation in Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 (LOX1) Gene and the Risk of Coronary Artery Disease
Common genetic variation in the LOX1 gene may be associated with the risk of coronary artery disease in white women, and electrophoretic mobility shift assay data show that the 3′UTR polymorphic sequence affects the binding of a putative transcription factor in an allele-specific manner.