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Rate of release of medicaments from ointment bases containing drugs in suspension.
Higuchi's equation that expresses the rate of release of medicaments from ointments containing drugs in suspension has long been used for its surprisingly simple form and convenience. If initial drugExpand
Effects of sodium glycocholate and protease inhibitors on permeability of TRH and insulin across rabbit trachea.
The permeabilities of thyrotropin-releasing hormone (TRH) and insulin as model peptides were examined to characterize the tracheal epithelial barrier in in vitro experiments using excised rabbitExpand
Effects of Low-Viscosity Sodium Hyaluronate Preparation on the Pulmonary Absorption of rh-Insulin in Rats
Purpose: A low-viscosity formulation for pulmonary delivery of rh-insulin as model peptide drugs was developed using a solution of sodium hyaluronate. Method: The effects of different concentrationsExpand
Kinetic studies on drug disposition in rabbits. II. Dose dependent pharmacokinetics of sulfamethizole.
In order to evaluate dose-dependent sulfamethizole (SMZ) kinetics, 100, 300 and 1000 mg of SMZ was constantly infused over 5 min in rabbits and thereafter plasma and urine samples were collected atExpand
Influence of absorption enhancers (bile salts) and the preservative (benzalkonium chloride) on mucociliary function and permeation barrier function in rabbit tracheas.
Effects of bile salts and benzalkonium chloride on the ciliary beat activity (frequency) and the mucociliary transport rate of tracheas, and permeabilities of 6-carboxyfluorescein (6-CF; Mw 376) andExpand
Controlled release of plasmid DNA from cationized gelatin hydrogels based on hydrogel degradation.
This paper shows achievement of the in vivo controlled release of a plasmid DNA from a biodegradable hydrogel and the consequent regulation of gene expression period. Cationization of gelatin wasExpand
Oral delivery of insulin by using surface coating liposomes improvement of stability of insulin in GI tract
The potency of surface coating liposomes with some materials was investigated for oral delivery of peptide drugs. In vitro release of insulin, a model peptide, from liposomes in the bile saltsExpand
In vivo release and gene expression of plasmid DNA by hydrogels of gelatin with different cationization extents.
The objective of this paper is to investigate the in vivo release and gene expression of lacZ plasmid DNA (pSV-lacZ) by the hydrogels of cationized gelatin. Gelatin with different cationizationExpand
Application of polyethyleneglycol (PEG)-modified liposomes for oral vaccine: effect of lipid dose on systemic and mucosal immunity.
To examine the systemic and mucosal immunity towards a liposomal antigen in an oral vaccine, we prepared ovalbumin (OVA)-encapsulating polyethyleneglycol (PEG)-modified liposomes and unmodified ones,Expand
Disposition of lipid-based formulation in the intestinal tract affects the absorption of poorly water-soluble drugs.
Solvent Green 3 (SG), a model poorly water-soluble compound, was orally administered to rats with soybean oil emulsion or the Self-microemulsifying drug delivery system (SMEDDS) composed ofExpand