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Rac, a small guanosine triphosphate-binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin alpha(2)beta(1).
It is suggested that Rac and/or PAK activation, but not Rho, may play certain roles in platelet spreading via integrin alpha(2)beta(1) and that Src family kinases and PI3-kinase participate in these processes.
Prostacyclin and beraprost sodium as suppressors of activated rat polymorphonuclear leukocytes.
The results suggest that the inhibitory effect of beraprost on the PMN function especially chemotaxis is mediated through the elevation of the intracellular cAMP level, which interferes with the signal transduction process probably through the inhibition of Ca2+ mobilization in PMNs.
Enhancement by beraprost sodium, a stable analogue of prostacyclin, in thrombomodulin expression on membrane surface of cultured vascular endothelial cells via increase in cyclic AMP level.
It is suggested that TM expression is positively regulated by cAMP in HUVEC, and that beraprost may be potentially effective for reducing thrombotic events through the mechanism which initiates the stimulation of cAMP/TM system in vascular endothelial cells.
Inhibition by beraprost sodium of thrombin-induced increase in endothelial macromolecular permeability.
- R. Imai-Sasaki, M. Kainoh, Y. Ogawa, E. Ohmori, Y. Asai, T. Nakadate
- Chemistry, MedicineProstaglandins, leukotrienes, and essential fatty…
- 1 August 1995
It is suggested that B PS suppressed the thrombin-induced macromolecular permeability in HUVEC through the elevation of its intracellular cAMP, and that BPS was a suppressor against inflammatory vascular changes such as exudation.
Rhodocytin induces platelet aggregation by interacting with glycoprotein Ia/IIa (GPIa/IIa, Integrin alpha 2beta 1). Involvement of GPIa/IIa-associated src and protein tyrosine phosphorylation.
- K. Suzuki-Inoue, Y. Ozaki, +7 authors T. Morita
- Chemistry, MedicineThe Journal of biological chemistry
- 12 January 2001
Rhodocytin, purified from the Calloselasma rhodostoma venom, induces platelet aggregation, which can be blocked by anti-GPIa monoclonal antibodies, and Src specifically associates with p130 Crk-associated substrate (Cas) in a manner dependent upon Cas phosphorylation, suggesting that Src is responsible for Cas tyrosineosphorylation.
Salvianolic acid B inhibits platelet adhesion under conditions of flow by a mechanism involving the collagen receptor alpha2beta1.
Results indicate that SAB inhibits platelet adhesion to immobilized collagen by interfering with the collagen receptor alpha2beta1.
Cytoprotective action of beraprost sodium against peroxide-induced damage in vascular endothelial cells.
Beraprost sodium (beraprost) significantly inhibited the decrease in viability of the cells and the increase in lipid peroxides level caused by t-butyl hydroperoxide or 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, suggesting that beraprost may be useful for protecting cells from damage due to ischemic diseases.
A Novel MitoNEET Ligand, TT01001, Improves Diabetes and Ameliorates Mitochondrial Function in db/db Mice
- Takehiro Takahashi, Masashi Yamamoto, +10 authors M. Kainoh
- Biology, MedicineThe Journal of Pharmacology and Experimental…
- 1 February 2015
The results suggest that TT01001 improved type II diabetes without causing weight gain and ameliorated mitochondrial function of db/db mice, and support targeting mitoNEET as a potential therapeutic approach for the treatment of type IIabetes.
Analgesic effect of GT-0198, a structurally novel glycine transporter 2 inhibitor, in a mouse model of neuropathic pain.
- Yumiko Omori, Mayumi Nakajima, +5 authors M. Kainoh
- Chemistry, MedicineJournal of pharmacological sciences
- 1 March 2015
GT-0198 is a structurally novel GlyT2 inhibitor bearing a phenoxymethylbenzamide moiety with in vivo efficacy in behavioral models of neuropathic pain and is considered to exhibit its analgesic effect via the activation of a glycine receptor by glycine following presynaptic GlyT 2 inhibition in the spinal cord.
Glycoprotein Ia/IIa-mediated activation-dependent platelet adhesion to collagen.
It is provided the first direct evidence that the activation-dependent platelet adhesion to collagen is induced by ADP and that GPIa/IIa also plays an important role in the mechanisms of this adhesion.