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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Yeast Sir2 is a heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extendsExpand
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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.
The SIR genes are determinants of life span in yeast mother cells. Here we show that life span regulation by the Sir proteins is independent of their role in nonhomologous end joining. The short lifeExpand
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mTOR is a key modulator of ageing and age-related disease
Many experts in the biology of ageing believe that pharmacological interventions to slow ageing are a matter of 'when' rather than 'if'. A leading target for such interventions is the nutrientExpand
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Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
Calorie restriction (CR) extends lifespan in a wide spectrum of organisms and is the only regimen known to lengthen the lifespan of mammals. We established a model of CR in budding yeastExpand
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Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients
Calorie restriction increases life span in many organisms, including the budding yeast Saccharomyces cerevisiae. From a large-scale analysis of 564 single-gene–deletion strains of yeast, weExpand
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Replicative and chronological aging in Saccharomyces cerevisiae.
Saccharomyces cerevisiae has directly or indirectly contributed to the identification of arguably more mammalian genes that affect aging than any other model organism. Aging in yeast is assayedExpand
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A molecular mechanism of chronological aging in yeast
The molecular mechanisms that cause organismal aging are a topic of intense scrutiny and debate. Dietary restriction extends the life span of many organisms, including yeast, and efforts are underwayExpand
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Histone H4 lysine-16 acetylation regulates cellular lifespan
Cells undergoing developmental processes are characterized by persistent non-genetic alterations in chromatin, termed epigenetic changes, represented by distinct patterns of DNA methylation andExpand
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Extension of chronological life span in yeast by decreased TOR pathway signaling.
Chronological life span (CLS) in Saccharomyces cerevisiae, defined as the time cells in a stationary phase culture remain viable, has been proposed as a model for the aging of post-mitotic tissues inExpand
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Lessons on longevity from budding yeast
This corrects the article DOI: 10.1038/nature08981
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