• Publications
  • Influence
Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice.
The cytosolic phosphoenolpyruvate carboxykinase (PEPCK) gene is expressed in multiple tissues and is regulated in a complex tissue-specific manner. To map the cis-acting DNA elements that direct thisExpand
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Correlation of leukemogenic potential of murine retroviruses with transcriptional tissue preference of the viral long terminal repeats.
Recombination studies have established that retroviral long terminal repeats (LTRs) are important genetic determinants of the viral capacity to induce hematopoietic tumors and to specify the type ofExpand
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Identification and characterization of Magmas, a novel mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction.
OBJECTIVE The aim of this study was to identify granulocyte-macrophage colony-stimulating factor (GM-CSF) responsive genes. MATERIALS AND METHODS Potential GM-CSF responsive genes were identifiedExpand
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Essential role of Drosophila black‐pearl is mediated by its effects on mitochondrial respiration
Black‐pearl (Blp) is a highly conserved, essential inner‐mitochondrial membrane protein. The yeast Blp homologue, Magmas/Pam16, is required for mitochondrial protein transport, growth, and survival.Expand
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Differences in activities of murine retroviral long terminal repeats in cytotoxic T lymphocytes and T-lymphoma cells.
Transcriptional activities of the long terminal repeats (LTRs) of various murine leukemia viruses were tested in the cytotoxic T-cell lines CTLL-1 and CTLL-2. In contrast to T-lymphoma cells, inExpand
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Contribution of Antibody Heavy Chain CDR1 to Digoxin Binding Analyzed by Random Mutagenesis of Phage-displayed Fab 26-10 (*)
We constructed a bacteriophage-displayed library containing randomized mutations at H chain residues 30-35 of the anti-digoxin antibody 26-10 Fab to investigate sequence constraints necessary forExpand
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Magmas expression in neoplastic human prostate
Magmas, is a 13-kDa mitochondrial protein which is ubiquitously expressed in eukaryotic cells. It was identified as a granulocyte-macrophage-colony stimulating factor (GM-CSF) inducible gene inExpand
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A single H:CDR3 residue in the anti-digoxin antibody 26-10 modulates specificity for C16-substituted digoxin analogs.
We constructed Fab libraries of bacteriophage-displayed H:CDR3 mutants in the high-affinity anti-digoxin antibody 26-10 to determine structural constraints on affinity and specificity for digoxin.Expand
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Complementary Combining Site Contact Residue Mutations of the Anti-digoxin Fab 26–10 Permit High Affinity Wild-type Binding*
Antibody 26–10, obtained in a secondary immune response, binds digoxin with high affinity (K a = 1.3 × 1010 m −1) because of extensive shape complementarity. We demonstrated previously that mutationsExpand
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Design, synthesis, and biological activity of novel Magmas inhibitors.
Magmas (mitochondria associated, granulocyte-macrophage colony stimulating factor signaling molecule), is a highly conserved and essential gene, expressed in all cell types. We designed andExpand
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