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Genomic DNA Hypomethylation by Histone Deacetylase Inhibition Implicates DNMT1 Nuclear Dynamics
ABSTRACT Histone deacetylase inhibitors (HDACi) are promising antitumor drugs acting through reactivation of silenced tumor suppressor genes. Several HDACi are currently in clinical trials both forExpand
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Mutation in ADORA1 identified as likely cause of early‐onset parkinsonism and cognitive dysfunction
We aimed to identify the genetic cause of neurological disease in an Iranian family whose manifestations include symptoms of parkinsonism and cognitive dysfunction.
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Study of a Polymerase Chain Reaction-based Method for Detection of Herpes Simplex Virus Type 1 DNA among Iranian Patients with Ocular Herpetic Keratitis Infection
PurposeTo study the presence of the herpes simplex virus type 1 (HSV-1) glycoprotein D gene in tear films of Iranian patients with herpetic keratitis.MethodsTwenty-five tear film and eye swabExpand
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  • Open Access
Selenite and methylseleninic acid epigenetically affects distinct gene sets in myeloid leukemia: A genome wide epigenetic analysis
ABSTRACT Selenium compounds have emerged as promising chemotherapeutic agents with proposed epigenetic effects, however the mechanisms and downstream effects are yet to be studied. Here we assessedExpand
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Genome-Wide DNA Methylation Analysis Shows Enrichment of Differential Methylation in “Open Seas” and Enhancers and Reveals Hypomethylation in DNMT3A Mutated Cytogenetically Normal AML (CN-AML)
Abstract 653 DNA methylation is involved in multiple biologic processes including normal cell differentiation and tumorigenesis. In AML, methylation patterns have been shown to differ significantlyExpand
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Pre-Symptomatic Human Cytomegalovirus Disease Diagnosis in Renal Transplant Recipients by the Virus DNA PCR
Human cytomegalovirus (HCMV, CMV) is a major infectious complication of renal transplantation. The objective of this survey was to optimize and establish a polymerase chain reaction (PCR) techniqueExpand
Novel Real Time Polymerase Chain Reaction Approach for Rapid Detection of the Residual Escherichia coli Genomic DNA in Biopharmaceutical Products Establishment of Real Time Polymerase Chain Reaction
Background: Contamination of therapeutic recombinant proteins with residual host cell DNA must be controlled under the regulatory standards. Objectives: The current study established a new rapid,Expand
GENOMIC DNA METHYLATION IN HEALTH AND DISEASE
Cytosine methylation is one of the important epigenetic mechanisms controlling the vertebrate genome. Changes in genomic DNA methylation have been demonstrated in aging, auto-immune diseases andExpand
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Growth and isolation of Human cytomegalovirus on a new human fetal foreskin fibroblast-derived cell line in Iran
Cell culture technique has been used for detection and confirmation of many different viruses in clinical sam- ples. Although, new diagnostic methods have been developed for viral infections,Expand
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  • Open Access