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Small-Conductance, Calcium-Activated Potassium Channels from Mammalian Brain
Members of a previously unidentified family of potassium channel subunits were cloned from rat and human brain and formed into calcium-activated, voltage-independent potassium channels, which contribute to the afterhyperpolarization in central neurons and other cell types.
Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS.
These results identify a switch in the molecular and functional properties of glutamate receptors operated by alternative splicing.
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels
RNA editing of AMPA receptor subunit GluR-B: A base-paired intron-exon structure determines position and efficiency
Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family.
The LH-CG-R gene may have evolved by recombination of LRG and G protein-coupled receptor genes and bind human choriogonadotropin with high affinity and show an increase in cyclic adenosine monophosphate when exposed to hormone.
Noninvasive in vivo imaging of pancreatic islet cell biology
The results thus establish the basis for noninvasive in vivo investigations of complex cellular processes, like beta cell stimulus-response coupling, which can be performed longitudinally under both physiological and pathological conditions.
Determinants of ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: Diversity by RNA editing
Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes
This animal model reproduces the β-cell pathology of human mitochondrial diabetes and provides genetic evidence for a critical role of the respiratory chain in insulin secretion.
Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration.
This study shows for the first time that high glucose concentrations and tolbutamide induce apoptosis in pancreatic beta-cells, and that this process is Ca2+-dependent.