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A twist code determines the onset of osteoblast differentiation.
Runx2 is necessary and sufficient for osteoblast differentiation, yet its expression precedes the appearance of osteoblasts by 4 days. Here we show that Twist proteins transiently inhibit Runx2… Expand
Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail
- Z. Kibar, Kyle J. Vogan, N. Groulx, M. Justice, D. Underhill, P. Gros
- Biology, Medicine
- Nature Genetics
- 1 July 2001
Neural tube defects (NTDs) such as spina bifida and anencephaly are common congenital malformations in humans (1/1,000 births) that result from failure of the neural tube to close during… Expand
A new family of mouse homeo box-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1.
Two families of homeo box-containing genes have been identified in mammals to date, the Antennapedia- and engrailed-like homeo boxes, based on the sequence similarity to those from Drosophila. Here,… Expand
Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice
Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes.… Expand
The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins
The mouse quaking gene, essential for nervous system myelination and survival of the early embryo has been positionally cloned. Its sequence implies that the locus encodes a multifunctional gene used… Expand
Gene defect in ectodermal dysplasia implicates a death domain adapter in development
Members of the tumour-necrosis factor receptor (TNFR) family that contain an intracellular death domain initiate signalling by recruiting cytoplasmic death domain adapter proteins. Edar is a death… Expand
High-throughput discovery of novel developmental phenotypes
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous insight into gene function and congenital… Expand
Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet–Biedl syndrome
- J. Tobin, M. Di Franco, +13 authors P. L. Beales
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 6 May 2008
Facial recognition is central to the diagnosis of many syndromes, and craniofacial patterns may reflect common etiologies. In the pleiotropic Bardet–Biedl syndrome (BBS), a primary ciliopathy with… Expand
The mutagenic action of N-ethyl-N-nitrosourea in the mouse
N-ethyl-N-nitrosourea (ENU) has become one of the most powerful tools in mammalian genetics. It has the highest mutation rate of any germline mutagen tested in the mouse, allowing phenotypedriven… Expand
Inactivation of Rai1 in mice recapitulates phenotypes observed in chromosome engineered mouse models for Smith-Magenis syndrome.
Retinoic acid induced 1 (RAI1) is among the 20 genes identified in the critical region of Smith-Magenis syndrome (SMS), a genomic disorder with multiple congenital anomalies associated with a 3.7 Mb… Expand