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Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans.
The molecular transducers of benefits from different exercise modalities remain incompletely defined. Here we report that 12 weeks of high-intensity aerobic interval (HIIT), resistance (RT), and… Expand
Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging.
- M. Johnson, B. Irving, +12 authors K. Nair
- The journals of gerontology. Series A, Biological…
- 1 November 2015
Acute aerobic exercise increases reactive oxygen species and could potentially damage proteins, but exercise training (ET) enhances mitochondrial respiration irrespective of age. Here, we report a… Expand
Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis.
Caloric restriction (CR) mitigates many detrimental effects of aging and prolongs life span. CR has been suggested to increase mitochondrial biogenesis, thereby attenuating age-related declines in… Expand
Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet.
- I. Lanza, A. Błachnio-Zabielska, +6 authors P. Zabielski
- Biology, Medicine
- American journal of physiology. Endocrinology and…
- 15 June 2013
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) enhance insulin sensitivity and glucose homeostasis in rodent models of insulin resistance. These beneficial effects have been linked with… Expand
Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults
Caloric restriction (CR) improves insulin sensitivity and reduces the incidence of diabetes in obese individuals. The underlying mechanisms whereby CR improves insulin sensitivity are not clear. We… Expand
Skeletal muscle aging and the mitochondrion
Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging process. A growing body of research in the areas of bioenergetics and protein turnover has placed the mitochondria at… Expand
Effects of Dietary n-3 Fatty Acids on Hepatic and Peripheral Insulin Sensitivity in Insulin-Resistant Humans
- Antigoni Z. Lalia, M. Johnson, M. Jensen, K. Hames, J. Port, I. Lanza
- Diabetes Care
- 7 April 2015
OBJECTIVE Dietary n-3 polyunsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), prevent insulin resistance and stimulate mitochondrial biogenesis in rodents,… Expand
Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice
Mitochondrial dysfunction is often observed in aging skeletal muscle and is implicated in age‐related declines in physical function. Early evidence suggests that dietary omega‐3 polyunsaturated fatty… Expand
Predictors of Whole-Body Insulin Sensitivity Across Ages and Adiposity in Adult Humans.
- Antigoni Z. Lalia, S. Dasari, +8 authors I. Lanza
- Biology, Medicine
- The Journal of clinical endocrinology and…
- 1 February 2016
CONTEXT Numerous factors are purported to influence insulin sensitivity including age, adiposity, mitochondrial function, and physical fitness. Univariate associations cannot address the complexity… Expand