The early identification of anticonvulsant activity: role of the maximal electroshock and subcutaneous pentylenetetrazol seizure models
- H. White, M. Johnson, H. Wolf, H. Kupferberg
- Psychology, MedicineThe Italian journal of neurological sciences…
- 1 February 1995
This chapter will briefly describe how the maximal electroshock and subcutaneous pentylenetetrazol tests are conducted, their limitations and how they have contributed in the past and to the present day anticonvulsant drug discovery process.
Effects of cocaine on extrapyramidal and limbic dynorphin systems.
- P. Smiley, M. Johnson, L. Bush, J. Gibb, G. Hanson
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1 June 1990
The response of extrapyramidal and limbic dynorphin A1-17 (Dyn) systems to cocaine was evaluated by measuring Dyn content in associated structures and the neurochemical response of Dyn systems to both of these agents is compared.
Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine.
- D. Stone, M. Johnson, G. Hanson, J. Gibb
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1 October 1988
Results implicate endogenous drug-released dopamine as a partial mediator of the initial decrease in TPH activity caused by MDMA and as an important prerequisite to the development of long-term MDMA-induced neurotoxicity.
Body temperature effect on methylenedioxymethamphetamine-induced acute decrease in tryptophan hydroxylase activity.
- S. Che, M. Johnson, G. Hanson, J. Gibb
- Biology, ChemistryEuropean Journal of Pharmacology
- 7 December 1995
A comparison of the neurotoxic potential of methylenedioxyamphetamine (MDA) and its N-methylated and N-ethylated derivatives.
- D. Stone, M. Johnson, G. Hanson, J. Gibb
- Chemistry, BiologyEuropean Journal of Pharmacology
- 10 February 1987
Distinct features of seizures induced by cocaine and amphetamine analogs.
- G. Hanson, M. Jensen, M. Johnson, H. White
- Biology, PsychologyEuropean Journal of Pharmacology
- 21 July 1999
Neurotoxicity of amphetamines and their metabolites.
- J. Gibb, M. Johnson, I. Elayan, H. Lim, L. Matsuda, G. Hanson
- Biology, PsychologyNIDA research monograph
- 1997
When amphetamine or an analog is administered in repeated high doses, neurochemical deficits in both the dopaminergic and serotonergic systems of selected areas of the brain are observed and persist in rats and nonhuman primates for extended periods of time after the drug is discontinued.
Effects of 3,4-dihydroxymethamphetamine and 2,4,5-trihydroxymethamphetamine, two metabolites of 3,4-methylenedioxymethamphetamine, on central serotonergic and dopaminergic systems.
- M. Johnson, I. Elayan, G. Hanson, R. Foltz, J. Gibb, H. Lim
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 May 1992
The results suggest that THM, but not DHM, is toxic to both dopaminergic and serotonergic nerve terminals, and its properties may prove useful in elucidating amphetamine toxicity.
Acute inactivation of tryptophan hydroxylase by amphetamine analogs involves the oxidation of sulfhydryl sites.
- D. Stone, M. Johnson, G. Hanson, J. Gibb
- Biology, ChemistryEuropean Journal of Pharmacology
- 7 March 1989
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