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Roles of Disrupted-In-Schizophrenia 1-Interacting Protein Girdin in Postnatal Development of the Dentate Gyrus
Disrupted-In-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders, regulates neuronal migration and differentiation during mammalian brain development. Although roles forExpand
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An actin-binding protein Girdin regulates the motility of breast cancer cells.
Girdin (girders of actin filaments) is a novel actin-binding Akt substrate that plays an important role in actin organization and Akt-dependent cell motility in fibroblasts. Here, we find that GirdinExpand
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Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities
We developed a simple algorithm, i-Score (inhibitory-Score), to predict active siRNAs by applying a linear regression model to 2431 siRNAs. Our algorithm is exclusively comprised of nucleotide (nt)Expand
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The RET proto‐oncogene: A molecular therapeutic target in thyroid cancer
The RET proto‐oncogene is responsible for the development of several human inherited and non‐inherited diseases. Germline point mutations were identified in multiple endocrine neoplasia types 2A andExpand
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CD44v6 Regulates Growth of Brain Tumor Stem Cells Partially through the AKT-Mediated Pathway
Identification of stem cell-like brain tumor cells (brain tumor stem-like cells; BTSC) has gained substantial attention by scientists and physicians. However, the mechanism of tumor initiation andExpand
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RET receptor signaling: Dysfunction in thyroid cancer and Hirschsprung's disease
Gain‐of‐function mutations within the receptor tyrosine kinase gene RET cause inherited and non‐inherited thyroid cancer. Somatic gene rearrangements of RET have been found in papillary thyroidExpand
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RET and neuroendocrine tumors
The RET proto-oncogene encodes a receptor tyrosine kinase that is a main component of the signaling pathway activated by the glial cell line-derived neurotrophic factor family ligands. Gene targetingExpand
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A Targeting Mutation of Tyrosine 1062 in Ret Causes a Marked Decrease of Enteric Neurons and Renal Hypoplasia
ABSTRACT The Ret receptor tyrosine kinase plays a crucial role in the development of the enteric nervous system and the kidney. Tyrosine 1062 in Ret represents a binding site for theExpand
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Functional Differences between GDNF-Dependent and FGF2-Dependent Mouse Spermatogonial Stem Cell Self-Renewal
Summary Spermatogonial stem cells (SSCs) are required for spermatogenesis. Earlier studies showed that glial cell line-derived neurotrophic factor (GDNF) was indispensable for SSC self-renewal byExpand
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Stretch-Induced Hypertrophy Activates NFkB-Mediated VEGF Secretion in Adult Cardiomyocytes
Hypertension and myocardial infarction are associated with the onset of hypertrophy. Hypertrophy is a compensatory response mechanism to increases in mechanical load due to pressure or volumeExpand
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