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Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies
TLDR
The current understanding of the pathophysiology underlying keloid and hypertrophic scar formation is summarized and established treatments and novel therapeutic strategies are discussed.
A genomic storm in critically injured humans
TLDR
It is shown that critical injury in humans induces a genomic storm with simultaneous changes in expression of innate and adaptive immunity genes that alter the status of these genes in the immune system.
Genomic responses in mouse models poorly mimic human inflammatory diseases
TLDR
This study shows that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses in corresponding mouse models correlate poorly with the human conditions and also, one another.
Hydrogen sulfide is an endogenous stimulator of angiogenesis
TLDR
Investigation of the role of exogenous and endogenous hydrogen sulfide on neovascularization and wound healing in vitro and in vivo concludes that endogenous and exogenous H2S stimulates EC-related angiogenic properties through a KATP channel/MAPK pathway.
Long-Term Persistance of the Pathophysiologic Response to Severe Burn Injury
TLDR
Severe burn injury leads to a much more profound and prolonged hypermetabolic and hyperinflammatory response than previously shown, and treatment needs for severely burned patients for a muchMore prolonged time are identified.
Pathophysiologic Response to Severe Burn Injury
TLDR
It is concluded that the postburn response is profound, occurring in a timely manner, with derangements that are greater and more protracted than previously thought.
Emerging infections in burns.
TLDR
Innovations in fluid management, ventilatory support, surgical care, and antimicrobial therapy have contributed to a significant reduction in morbidity and mortality rates in burn patients.
Methodologies in creating skin substitutes
TLDR
The five necessary attributes of an ideal skin substitute are discussed and a variety of techniques in how to incorporate these basic components together are examined to act as a guide for further research in the field to create cellular skin substitutes with better clinical results.
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