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Identification of a novel gene involved in pilin glycosylation in Neisseria meningitidis
TLDR
Insertional mutations were constructed in pglA in a range of meningococcal strains with well‐defined lipopolysaccharide (LPS) or pilin‐linked glycan structures to determine whether p glA had a role in the biosynthesis of these molecules, suggesting that PglA is a glycosyltransferase involved in the addition of galactose of the trisaccharide substituent of pilin. Expand
Defenses against Oxidative Stress in Neisseria gonorrhoeae: a System Tailored for a Challenging Environment
TLDR
This review describes recent advances in the understanding of defense systems against oxidative stress in N. gonorrhoeae and shows that while some of its defenses have similarities to the paradigm established with Escherichia coli, there are also some key differences. Expand
Meningococcal pilin: a glycoprotein substituted with digalactosyl 2,4‐diacetamido‐2,4,6‐trideoxyhexose
TLDR
These studies have confirmed the previous observations that meningococcal pili are glycosylated and provided the first structural evidence for the presence of covalently linked carbohydrate on pili, and revealed a completely novel protein/saccharide linkage. Expand
Identification, Characterization and Immunogenicity of an O-Antigen Capsular Polysaccharide of Francisella tularensis
TLDR
It is demonstrated that F. tularensis produces an O-antigen capsule that may be the basis of a future vaccine and mass spectrometry, compositional analysis and NMR indicate that the capsule is composed of a polymer of the tetrasaccharide repeat. Expand
Virulence of Streptococcus pneumoniae: PsaA Mutants Are Hypersensitive to Oxidative Stress
TLDR
It is shown that psaA and psaD mutants are highly sensitive to oxidative stress, i.e., to superoxide and hydrogen peroxide, which might explain why they are less virulent than the wild-type strain. Expand
Molecular analysis of the psa permease complex of Streptococcus pneumoniae
TLDR
Inductively coupled plasma mass spectrometry (ICP‐MS) analysis provided the first direct evidence that PsaBCA is indeed a Mn2+ transporter, but this study did not substantiate previous reports that the locus plays a role in choline‐binding protein pro‐duction or chain morphology. Expand
Defenses against oxidative stress in Neisseria gonorrhoeae and Neisseria meningitidis: distinctive systems for different lifestyles.
TLDR
It is shown that accumulation of Mn also confers resistance to hydrogen peroxide killing via a catalase-independent mechanism and differences in oxidative defenses in the pathogenic Neisseria are most likely a result of their localization in different ecological niches. Expand
The genetic basis of the phase variation repertoire of lipopolysaccharide immunotypes in Neisseria meningitidis.
TLDR
A locus of three LPS biosynthetic genes involved in the biosynthesis of one of these terminal structures, lacto-N-neotetraose, was examined, and the potential for strains to express alternative immunotypes was established. Expand
A random six-phase switch regulates pneumococcal virulence via global epigenetic changes
TLDR
This work demonstrates distinct virulence in experimental infection and in vivo selection for switching between SpnD39III variants, which is ubiquitous in pneumococci, indicating an essential role in its biology. Expand
The Staphylococcal Toxins γ-Hemolysin AB and CB Differentially Target Phagocytes by Employing Specific Chemokine Receptors
TLDR
Functional quantification identifies HlGAB and HlgCB as major secreted staphylococcal leukocidins and hlgAB-mediated targeting of CCR2+ cells highlights the involvement of inflammatory macrophages during S. aureus infection. Expand
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