• Publications
  • Influence
The role of mitogen-activated protein (MAP) kinase in breast cancer
  • R. Santen, R. Song, +4 authors W. Yue
  • Medicine, Biology
  • The Journal of Steroid Biochemistry and Molecular…
  • 1 February 2002
Direct experimental data demonstrate that the pressure of estradiol deprivation results in the upregulation of MAP kinase in breast cancer cells growing in tissue culture and as xenografts, and larger numbers of patients must be studied for these results to achieve statistical significance. Expand
EphA2 overexpression decreases estrogen dependence and tamoxifen sensitivity.
It is demonstrated that overexpression of EphA2 decreases estrogen dependence as defined using both in vitro and in vivo criteria, and this results have important implications for understanding the molecular basis underlying estrogen dependence. Expand
Adaptive hypersensitivity to estrogen: mechanism for superiority of aromatase inhibitors over selective estrogen receptor modulators for breast cancer treatment and prevention.
In vitro and in vivo evidence is provided that long-term E(2) deprivation (LTED) causes "adaptive hypersensitivity", which would explain the superiority of aromatase inhibitors over the selective ER modulators (SERMs) for treatment of breast cancer. Expand
Estrogenic potential of progestins in oral contraceptives to stimulate human breast cancer cell proliferation.
Direct evidence is provided that the 19-nortestosterone derivatives in OC have estrogenic properties and suggests that activation of ER, but not progesterone receptor, is the growth-stimulatory mechanism for these synthetic progestins. Expand
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen‐independent status
It remains to be determined whether CARM1 is involved in prostatic carcinogenesis, but it is likely that it is not. Expand
HOXB13 Induces Growth Suppression of Prostate Cancer Cells as a Repressor of Hormone-Activated Androgen Receptor Signaling
The results suggest that HOXB13 functions as an AR repressor to modulate the complex AR signaling and subsequent growth regulation of prostate cancer cells, which can be interpreted to a growth-suppressive event. Expand
Novel prostate-specific promoter derived from PSA and PSMA enhancers.
  • Sang-Jin Lee, H. Kim, +7 authors C. Kao
  • Biology, Medicine
  • Molecular therapy : the journal of the American…
  • 1 September 2002
The potential use of PSES for the treatment of androgen-independent prostate cancer patients is demonstrated and the high tissue-specificity of the PSES promoter in an adenoviral vector is demonstrated. Expand
The role of interleukin‐12 on modulating myeloid‐derived suppressor cells, increasing overall survival and reducing metastasis
A novel role is identified for IL‐12 as a modulator of immune suppression with significant potential as a therapeutic agent for metastatic breast cancer. Expand
Estrogen receptor expression and function in long-term estrogen-deprived human breast cancer cells.
It is suggested that long-term estradiol deprivation causes adaptive processes that not only involve up-regulation of the ER but also influence the specificity and magnitude of activation of estrogen-responsive genes. Expand
Inhibition of tamoxifen-stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens.
These studies confirm and extend the previous observation on TAM-stimulated growth of breast cancer cells in vivo and demonstrate the possibility of developing novel antiestrogens to prevent this form of drug resistance should it occur in the clinic. Expand