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Formation of oxy radicals by oxygen reduction arising from the surface activity of asbestos
Formation of hydroxyl radicals, in relatively large quantities, by oxygen reduction due to the surface activity of asbestos in a cell-free system is demonstrated, using electron spin resonance and ...
Molecular changes in mesothelioma with an impact on prognosis and treatment.
- D. Jean, J. Daubriac, F. Le Pimpec-Barthes, F. Galateau-Sallé, M. Jaurand
- Biology, Medicine
- Archives of pathology & laboratory medicine
- 28 February 2012
CONTEXT In recent decades, research on malignant pleural mesothelioma (MPM) has been developed to improve patients' outcomes by increasing the level of confidence in MPM diagnosis and prognosis. … Expand
Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres
Presented here is information on the mechanisms of action of different dusts and fibres of industrial interest. Emphasis is placed on the use of cell and organ culture, and lavage cell populations… Expand
Similar Tumor Suppressor Gene Alteration Profiles in Asbestos-Induced Murine and Human Mesothelioma
The status of tumor suppressor genes (TSGs) relevant to human malignant mesothelioma (HMM) pathogenesis was examined in cultures of mesothelioma cells from tumoral ascites developed in mice exposed… Expand
Pathogenesis of malignant pleural mesothelioma
Abstract: Malignant pleural mesothelioma (MPM) results from neoplastic transformation of mesothelial cells. Past asbestos exposure represents the major risk factor for MPM, as the link between… Expand
Biomarkers in risk assessment of asbestos exposure.
Developments in the field of molecular epidemiology and toxicology have given valuable tools for early detection of impending disease or toxic condition. Morbidity due to respiratory distress, which… Expand
Nitrosulindac (NCX 1102): A new nitric oxide‐donating non‐steroidal anti‐inflammatory drug (NO‐NSAID), inhibits proliferation and induces apoptosis in human prostatic epithelial cell lines
The aim of our study was to explore the anti‐tumoral potential of the Nitric Oxide‐Donating Non‐Steroidal Anti‐Inflammatory Drugs (NO‐NSAID) NCX1102 (nitrosulindac), on three human prostatic… Expand
Antiproliferative effect of nitrosulindac (NCX 1102), a new nitric oxide-donating non-steroidal anti-inflammatory drug, on human bladder carcinoma cell lines.
- S. Huguenin, F. Vacherot, +5 authors D. Chopin
- Chemistry, Medicine
- Molecular cancer therapeutics
- 1 March 2004
Non-steroidal anti-inflammatory drugs (NSAIDs) are potent antitumoral agents but their side effects limit their clinical use. A novel class of drugs, nitric oxide-donating NSAIDs (NO-NSAIDs), was… Expand
Molecular Classification of Malignant Pleural Mesothelioma: Identification of a Poor Prognosis Subgroup Linked to the Epithelial-to-Mesenchymal Transition
- A. de Reyniès, M. Jaurand, +14 authors D. Jean
- Biology, Medicine
- Clinical Cancer Research
- 17 January 2014
Purpose: Despite research efforts to develop more effective diagnostic and therapeutic approaches, malignant pleural mesothelioma (MPM) prognosis remains poor. The assessment of tumor response to… Expand