Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.
FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1
A molecular and morphological characterization of the major steps in the maturation of the primary lymphatic capillary plexus into collecting lymphatic vessels during development is provided and show that forkhead transcription factor Foxc2 controls this process.
Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
It is shown that mice deficient for S6 kinase 1, an effector of the phosphatidylinositide-3-OH kinase signalling pathway, are hypoinsulinaemic and glucose intolerant, which closely parallels those of preclinical type 2 diabetes mellitus, in which malnutrition-induced hypo insulinaemia predisposes individuals to glucose intolerance.
Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice
Modulation of gut microbiota via antibiotics administration ameliorated glucose tolerance of mice by altering the expression of hepatic and intestinal genes involved in inflammation and metabolism, and by changing the hormonal, inflammatory, and metabolic status of the host.
Impact of coffee consumption on the gut microbiota: a human volunteer study.
Bmi1 Loss Produces an Increase in Astroglial Cells and a Decrease in Neural Stem Cell Population and Proliferation
Bmi1 is expressed in the germinal zone in vivo and in NSCs as well as in progenitors proliferating in vitro, but not in differentiated cells, and the altered cell pattern of the Bmi1-/- brain shows that in vivo astrocyte precursors can proliferate in the absence of Bmi 1.
DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport.
- J. Bernier-Latmani, Christophe Cisarovsky, T. Petrova
- BiologyJournal of Clinical Investigation
- 1 December 2015
It is proposed that such a slow lymphatic regeneration mode is necessary to match a unique need of intestinal lymphatic vessels for both continuous maintenance, due to the constant exposure to dietary fat and mechanical strain, and efficient uptake of fat and immune cells.
FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature.
An important role is identified for disturbed flow in lymphatic vessels, in which it cooperates with the transcription factor FOXC2 to ensure lifelong stability of the lymphatic vasculature and provides an essential link between biomechanical forces and endothelial cell identity that is necessary for postnatal vessel homeostasis.
Transgenic Reexpression of GLUT1 or GLUT2 in Pancreatic β Cells Rescues GLUT2-null Mice from Early Death and Restores Normal Glucose-stimulated Insulin Secretion*
- B. Thorens, M. Guillam, F. Beermann, R. Burcelin, M. Jaquet
- Biology, MedicineJournal of Biological Chemistry
- 4 August 2000
It is demonstrated that normal GSIS does not depend on transporter affinity but on the rate of uptake at stimulatory glucose concentrations and can be restored as well by GLUT1 or GLUT2, and this was accompanied by normalization of the glucose utilization rate.
Physiological and biochemical characterization of the two alpha-L-rhamnosidases of Lactobacillus plantarum NCC245.
This work identified and characterized the strain L. plantarum NCC245 and its two alpha-l-rhamnosidase enzymes, which might be applied for improvement of bioavailability of health-beneficial polyphenols, such as hesperidin, in humans.