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Brazilian Sepsis Epidemiological Study (BASES study)
IntroductionConsistent data about the incidence and outcome of sepsis in Latin American intensive care units (ICUs), including Brazil, are lacking. This study was designed to verify the actualExpand
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Regulation of NAD(P)H Oxidase by Associated Protein Disulfide Isomerase in Vascular Smooth Muscle Cells*
NAD(P)H oxidase, the main source of reactive oxygen species in vascular cells, is known to be regulated by redox processes and thiols. However, the nature of thiol-dependent regulation has not beenExpand
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Noxa1 is a central component of the smooth muscle NADPH oxidase in mice.
NADPH oxidase is the most important source of oxygen-derived radicals (ROS) in the vascular wall. In vascular smooth muscle cells (VSMC), NADPH oxidase is characterized by the expression of theExpand
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Oxidative stress in the pathogenesis of nonalcoholic fatty liver disease, in rats fed with a choline‐deficient diet
Background/Aim: The pathogenesis of Nonalcoholic Fatty Liver Disease remains largely unknown, but oxidative stress seems to be involved. The aim of this study was to evaluate the role of oxidativeExpand
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Protein disulfide isomerase redox‐dependent association with p47phox: evidence for an organizer role in leukocyte NADPH oxidase activation
Mechanisms of leukocyte NADPH oxidase regulation remain actively investigated. We showed previously that vascular and macrophage oxidase complexes are regulated by the associated redox chaperone PDI.Expand
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Overestimation of NADH-driven vascular oxidase activity due to lucigenin artifacts.
Several limitations have recently been described for lucigenin, a probe frequently used to assess the activity of vascular NAD(P)H oxidase, a major superoxide source. The preferential reducingExpand
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Platelet-derived exosomes of septic individuals possess proapoptotic NAD(P)H oxidase activity: A novel vascular redox pathway*
ObjectiveVascular dysfunction in sepsis may involve apoptosis of vascular cells through redox signaling mechanisms, which are still poorly investigated. Platelets have been shown to produce reactiveExpand
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Functional role of NADPH oxidase in activation of platelets.
Involvement of phagocyte NADPH oxidase in host defense response is well established. In contrast, little is known about the functional role of NADPH oxidase in platelets. In this study, we analyzedExpand
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[37] Redox aspects of vascular response to injury
Publisher Summary The chapter discusses some specific aspects of vascular injury models and procedures for the assessment of reactive oxygen species (ROS), particularly superoxide, and NAD (P)HExpand
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