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Depression: a new animal model sensitive to antidepressant treatments
Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
Behavioral despair in mice: a primary screening test for antidepressants.
The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
"Behavioural despair" in rats and mice: strain differences and the effects of imipramine.
Important differences exist between strains in both the amount of immobility observed and the effects of imipramine, and strain differences should be taken into account in attempts to replicate results from one laboratory to another.
Immobility induced by forced swimming in rats: effects of agents which modify central catecholamine and serotonin activity.
It was concluded that immobility depended primarily on the activity of central catecholamines but that caution was required before ascribingimmobility exclusively to activity within a single system.
Forced swimming in rats: hypothermia, immobility and the effects of imipramine.
Rats when forced to swim in a restricted space not only became immobile but showed marked hypothermia, which can be dissociated from the immobility occurring in these conditions and also from drug-induced Hypothermia.
Neuroleptic-induced acute dyskinesias in rhesus monkeys
It is suggested that neuroleptic induced acute dyskinesias in the Rhesus monkey might be a useful model for predicting the liability of new anti-psychotics for inducing acute dyskinetic reactions in man.
Blockade of central 5-hydroxytryptamine receptors by methiothepin
Methiothepin was shown to be an antagonist of 5-hydroxytryptamine (5-HT) at receptors in the CNS by observing its effects on ponto-geniculo-occipital (PGO) spikes induced in curarized cats by either the benzoquinolizine Ro 4-1284 or p-chlorophenylalanine.
Drugs and PGO waves in the lateral geniculate body of the curarized cat. I. PGO wave activity induced by Ro 43284 and by p-chlorophenylalanine (PCPA) as a basis for neuropharmacological studies.
The present paper describes the characteristic qualitative and quantitative features of PGO1284 and PGOPCPA recorded under standard experimental conditions and provides the basis required for the following investigations of this series on the modulating effects of various drugs on this phasic brain activity.
Neuropharmacological profile of MD 790501, a new benzamide derivative.
Using several classical screening procedures in different species MD 790501: (exo)-2,3 dimethoxy-N-[8-(phenylmethyl)-8-azabiocyclo [3.2.1]oct-3-yl] benzamide hydrochloride was shown to possess potent