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- Publications
- Influence
In vivo and in vitro characterization of [18F]-FE-(+)-DTBZ as a tracer for beta-cell mass.
- O. Eriksson, M. Jahan, +4 authors L. Johansson
- Chemistry, Medicine
- Nuclear medicine and biology
- 1 April 2010
INTRODUCTION
The positron emission tomography (PET) tracer 9-[(18)F]fluoroethyl-(+)-dihydrotetrabenazine ([(18)F]-FE-(+)-DTBZ) is a potential candidate for quantifying beta-cell mass in vivo. The… Expand
Decreased defluorination using the novel beta-cell imaging agent [18F]FE-DTBZ-d4 in pigs examined by PET
- M. Jahan, O. Eriksson, +4 authors C. Halldin
- Medicine
- EJNMMI research
- 5 December 2011
BackgroundFluorine-18 dihydrotetrabenazine [DTBZ] analogues, which selectively target the vesicular monoamine transporter 2 [VMAT2], have been extensively studied for in vivo quantification of beta… Expand
In Vivo Visualization of β-Cells by Targeting of GPR44
- O. Eriksson, P. Johnström, +8 authors O. Korsgren
- Medicine
- Diabetes
- 1 December 2017
GPR44 expression has recently been described as highly β-cell selective in the human pancreas and constitutes a tentative surrogate imaging biomarker in diabetes. A radiolabeled small-molecule GPR44… Expand
Fluorine-18 labeling of three novel D-peptides by conjugation with N-succinimidyl-4-[18F]fluorobenzoate and preliminary examination by postmortem whole-hemisphere human brain autoradiography.
- M. Jahan, S. Nag, +7 authors C. Halldin
- Chemistry, Medicine
- Nuclear medicine and biology
- 1 April 2012
INTRODUCTION
β-Amyloid (Aβ) plaques and neurofibrillary tangles are the main characteristics of Alzheimer's disease (AD). Positron emission tomography (PET), a high-resolution, sensitive, and… Expand
Synthesis and biological evaluation of [¹¹C]AZ12504948; a novel tracer for imaging of glucokinase in pancreas and liver.
- M. Jahan, P. Johnström, +5 authors O. Eriksson
- Chemistry, Medicine
- Nuclear medicine and biology
- 1 April 2015
INTRODUCTION
Glucokinase (GK) is potentially a target for imaging of islets of Langerhans. Here we report the radiosynthesis and preclinical evaluation of the GK activator, [(11)C]AZ12504948, for in… Expand
Characterization of [11C]PXT012253 as a PET Radioligand for mGlu4 Allosteric Modulators in Nonhuman Primates
- A. Takano, S. Nag, +7 authors D. Charvin
- Chemistry, Medicine
- Molecular Imaging and Biology
- 1 June 2019
PurposeModulation of presynaptic metabotropic glutamate receptor 4 (mGlu4) by an allosteric ligand has been proposed as a promising therapeutic target in Parkinson’s disease and levodopa-induced… Expand
The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass
- M. Jahan, P. Johnström, +12 authors O. Eriksson
- Medicine
- EJNMMI Research
- 27 December 2018
BackgroundThe G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand.MethodsThe… Expand
Development of novel PET radioligands for visualizing beta cell mass and amyloid plaques
- M. Jahan
- Medicine
- 19 August 2016
- 3
PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [18F]PF-06684511
- R. Arakawa, A. Takano, +12 authors A. Varrone
- Medicine
- European Journal of Nuclear Medicine and…
- 6 March 2020
Beta-secretase 1 (BACE1) enzyme is implicated in the pathophysiology of Alzheimer’s disease. [18F]PF-06684511 is a positron emission tomography (PET) radioligand for imaging BACE1. Despite favorable… Expand
Synthesis, Biodistribution, and Radiation Dosimetry of a Novel mGluR5 Radioligand: 18F-AZD9272
- S. Nag, K. Varnäs, +4 authors C. Halldin
- Medicine
- ACS chemical neuroscience
- 13 March 2020
The metabotropic glutamate receptor subtype mGluR5 has been proposed as a potential drug target for CNS disorders such as anxiety, depression, Parkinson’s disease, and epilepsy. The AstraZeneca… Expand